Protein: CASL
Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]

Gene: CASL, NEDD9
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q14511

Gene Ontology (top 5):
GO:0000922 - spindle pole
GO:0001772 - immunological synapse
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

294859

BCAR3
Breast cancer anti-estrogen resistance protein 3

4

20

Small-scale

0.910

High

855872

CRKL
Crk-like protein

4

20

Small-scale

0.893

High

683456

IKBA
NF-kappa-B inhibitor alpha

3

8

High-throughput

0.871

High

855624

CRK
Adapter molecule crk

3

20

Small-scale

0.857

High

1127339

CASL
Enhancer of filamentation 1

2

14

Small-scale

0.807

High

942612

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

18

Small-scale

0.789

High

362290

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.754

High

463518

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.724

High

1050997

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.713

High

1014513

SMAD3
Mothers against decapentaplegic homolog 3

4

5

Small-scale

0.703

High

1127359

BANP
Protein BANP

5

0

High-throughput

0.689

High

1127343

TRIP6
Thyroid receptor-interacting protein 6

3

11

Small-scale

0.674

High

1127344

NAB2
NGFI-A-binding protein 2

4

0

High-throughput

0.673

High

1127356

DOCK3
Dedicator of cytokinesis protein 3

1

7

Small-scale

0.665

High

1127376

NOTC3
Neurogenic locus notch homolog protein 3

1

4

Small-scale

0.647

High

1127355

RFX6
DNA-binding protein RFX6

3

0

High-throughput

0.646

High

571974

TRI27
Zinc finger protein RFP

2

1

High-throughput

0.640

High

1127375

FZR1
Fizzy-related protein homolog

2

6

Small-scale

0.629

High

1127342

RHEB
GTP-binding protein Rheb

2

7

High-throughput

0.628

High

1048853

REL
Proto-oncogene c-Rel

2

7

High-throughput

0.628

High

1127363

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.623

High

1127362

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

11

High-throughput

0.621

High

440075

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.618

High

440558

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

1119089

RPGF1
Rap guanine nucleotide exchange factor 1

1

5

Small-scale

0.618

High

1124589

SRC8
Src substrate cortactin

1

20

Small-scale

0.618

High

1125283

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

1127358

SH2D3
SH2 domain-containing protein 3C

1

20

Small-scale

0.618

High

158726

BORG1
Cdc42 effector protein 2

2

1

High-throughput

0.606

High

256530

TBX19
T-box transcription factor TBX19

2

4

High-throughput

0.606

High

783269

TRI23
E3 ubiquitin-protein ligase TRIM23

2

4

High-throughput

0.606

High

885241

HXA1
Homeobox protein Hox-A1

2

2

High-throughput

0.606

High

921043

FOSB
Protein FosB

2

8

High-throughput

0.606

High

1090642

TRAF2
TNF receptor-associated factor 2

2

3

High-throughput

0.606

High

1127340

K1H2
Keratin, type I cuticular Ha2

2

2

High-throughput

0.606

High

1127350

EEIG1
Early estrogen-induced gene 1 protein

2

1

High-throughput

0.606

High

1127351

LHX8
LIM/homeobox protein Lhx8

2

12

High-throughput

0.606

High

1127353

DPPA4
Developmental pluripotency-associated protein 4

2

2

High-throughput

0.606

High

1127361

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.606

High

1127364

EXOS8
Exosome complex component RRP43

2

1

High-throughput

0.606

High

1127367

PRAM
PML-RARA-regulated adapter molecule 1

2

12

High-throughput

0.606

High

1127372

WWOX
WW domain-containing oxidoreductase

2

2

High-throughput

0.606

High

1127346

SMAD1
Mothers against decapentaplegic homolog 1

2

5

Small-scale

0.600

High

1127365

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

5

Small-scale

0.586

High

48953

MED19
Mediator of RNA polymerase II transcription subunit 19

2

0

High-throughput

0.580

High

50332

F168B
Myelin-associated neurite-outgrowth inhibitor

2

0

High-throughput

0.580

High

783701

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.580

High

1081364

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1127349

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

593997

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.561

High

1053663

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

3

Small-scale

0.561

High

1127360

MICA1
[F-actin]-monooxygenase MICAL1

1

8

Small-scale

0.561

High

1036515

ID2
DNA-binding protein inhibitor ID-2

1

1

Small-scale

0.552

High

1127369

DOCK9
Dedicator of cytokinesis protein 9

1

4

High-throughput

0.541

High

320823

KLH18
Kelch-like protein 18

1

2

High-throughput

0.536

High

1127374

TINAG
Tubulointerstitial nephritis antigen

1

2

High-throughput

0.536

High

333334

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

1127348

Q49AR9
ANKS1A protein

1

11

High-throughput

0.515

High

1127357

CARME
Carnosine N-methyltransferase

1

0

High-throughput

0.513

High

1086217

TFCP2
Alpha-globin transcription factor CP2

1

5

High-throughput

0.508

High

170136

AURKA
Aurora kinase A

1

2

Small-scale

0.501

High

422107

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

1050792

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

8

Small-scale

0.501

High

839010

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.486

High

1127366

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.486

High

517

NBPFJ
NBPF family member NBPF19

1

7

High-throughput

0.481

High

587470

TFE2
Transcription factor E2-alpha

1

1

Small-scale

0.481

High

1127347

ZYX
Zyxin

1

12

Small-scale

0.481

High

1127354

NT2NA
Notch homolog 2 N-terminal-like protein A

1

4

High-throughput

0.481

High

1127377

KLH20
Kelch-like protein 20

1

3

High-throughput

0.481

High

278862

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.480

High

424033

ITB3
Integrin beta-3

1

1

Small-scale

0.479

High

474677

VIME
Vimentin

1

8

Small-scale

0.479

High

551913

CO6A3

1

1

High-throughput

0.479

High

772800

MYH9
Myosin-9

1

2

Small-scale

0.479

High

878459

PAXI
Paxillin

1

10

Small-scale

0.479

High

1127341

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

1127345

SMAD2
Mothers against decapentaplegic homolog 2

1

5

Small-scale

0.479

High

1127371

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

5

Small-scale

0.479

High

517003

NT2NC
Notch homolog 2 N-terminal-like protein C

1

5

High-throughput

0.470

High

1017610

PR20C
Proline-rich protein 20C

1

1

High-throughput

0.470

High

1127368

Q9BS75
Kelch-like protein 20

1

3

High-throughput

0.470

High

1127352

CSPG4
Chondroitin sulfate proteoglycan 4

1

0

Small-scale

0.458

High

1127370

SAV1
Protein salvador homolog 1

1

8

Small-scale

0.457

High

919962

PLK1
Serine/threonine-protein kinase PLK1

1

6

Small-scale

0.445

High

1127373

TBK1
Serine/threonine-protein kinase TBK1

1

4

Small-scale

0.445

High

1017698

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High


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Last updated: 11Aug2025