Protein: CASS4
Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL)

Gene: CASS4
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q9NQ75

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton
GO:0005925 - focal adhesion
GO:0007155 - cell adhesion
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1279996

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

3

11

High-throughput

0.750

High

855768

CRK
Adapter molecule crk

1

20

High-throughput

0.691

High

1352056

MICA1
[F-actin]-monooxygenase MICAL1

3

8

High-throughput

0.655

High

158730

BORG1
Cdc42 effector protein 2

3

1

High-throughput

0.650

High

1156224

ZYX
Zyxin

3

13

High-throughput

0.650

High

243018

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.618

High

942908

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

17

High-throughput

0.618

High

1116594

FHL3
Four and a half LIM domains protein 3

2

10

High-throughput

0.606

High

326870

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

1

10

High-throughput

0.590

High

440742

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.590

High

1051064

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.590

High

1125302

FAK2
Protein-tyrosine kinase 2-beta

1

20

High-throughput

0.590

High

1416514

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

High-throughput

0.590

High

840987

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.575

High

1366038

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

11

High-throughput

0.528

High

1063632

GOGA2
Golgin subfamily A member 2

1

14

High-throughput

0.470

High

159272

ABLM1
Actin-binding LIM protein 1

1

9

High-throughput

0.457

High

535572

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.457

High

637747

FLNA
Filamin-A

1

3

High-throughput

0.457

High

928558

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.457

High

1050826

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

9

High-throughput

0.457

High

1093434

TRI32
E3 ubiquitin-protein ligase TRIM32

1

3

High-throughput

0.457

High

1112391

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

1

High-throughput

0.457

High

1112422

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

1

High-throughput

0.457

High

1123832

DCTN1
Dynactin subunit 1

1

9

High-throughput

0.457

High

1387113

REPS1
RalBP1-associated Eps domain-containing protein 1

1

7

High-throughput

0.457

High

1446808

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

3

High-throughput

0.457

High

60139

CCD78
Coiled-coil domain-containing protein 78

1

0

High-throughput

0.438

High

464398

ERCC1
DNA excision repair protein ERCC-1

1

0

High-throughput

0.438

High

882569

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.438

High

1326825

T11L2
T-complex protein 11-like protein 2

1

0

High-throughput

0.438

High

1364454

ELMO1
Engulfment and cell motility protein 1

1

0

High-throughput

0.438

High

473111

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.417

High

1419972

CRNL1
Crooked neck-like protein 1

1

5

High-throughput

0.417

High

1446807

DDX56
Probable ATP-dependent RNA helicase DDX56

1

3

High-throughput

0.417

High

269386

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

1181236

ATOSA
Atos homolog protein A

1

0

High-throughput

0.238

Low

1446809

SPIN1
Spindlin-1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025