HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: PACN3 (Q9UKS6)
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Gene: PACSIN3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19041431
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 424
+	Mm
		760485 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN3_MOUSE (1-424): 1.36e-93: 290: 94.34
+	Mm
		760475 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN1_MOUSE (1-422): 4.66e-86: 271: 48.53
+	Hs
		840812 DYN2_HUMAN (1-870): 0: 1057: 100.00		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86
+	Hs
		840864 DYN2_HUMAN (1-870): 0: 1057: 100.00		PACN2_HUMAN (4-422): 2.86e-77: 249: 48.96
+	Mm
		760451 DYN1_MOUSE (1-844): 0: 1003: 79.23		PACN1_MOUSE (1-422): 4.66e-86: 271: 48.53
+	Hs
		207784 DYN2_HUMAN (1-870): 0: 1057: 100.00		PPIP1_HUMAN (7-422): 4.41e-64: 213: 21.48
+	Hs
		983406 DYN1_HUMAN (1-846): 0: 1002: 79.04		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86
+	Mm
		760487 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN2_MOUSE (4-358): 3.84e-61: 207: 52.68
+	Hs
		840683 DYN2_HUMAN (1-870): 0: 1057: 100.00		MYO1E_HUMAN (2-422): 5.28e-39: 151: 14.03
+	Hs
		840700 DYN2_HUMAN (1-870): 0: 1057: 100.00		CIP4_HUMAN (16-365): 9.77e-38: 146: 17.05
+	Mm
		760473 DYN2_MOUSE (1-870): 0: 1057: 98.16		SRC8_MOUSE (162-421): 1.65e-36: 142: 17.84
+	Hs
		983372 DYN1_HUMAN (1-846): 0: 1002: 79.04		MYO1E_HUMAN (2-422): 5.28e-39: 151: 14.03
+	Hs
		983392 DYN1_HUMAN (1-846): 0: 1002: 79.04		NOSTN_HUMAN (22-424): 3.8e-37: 143: 13.91
+	Hs
		840702 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Mm
		760488 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (325-421): 5.3e-15: 79.4: 24.74
+	Hs
		840723 DYN2_HUMAN (1-870): 0: 1057: 100.00		FBP1L_HUMAN (190-421): 1.92e-12: 70.9: 13.82
+	Hs
		840798 DYN2_HUMAN (1-870): 0: 1057: 100.00		FNBP1_HUMAN (214-421): 7.83e-12: 69: 13.46
+	Mm
		760469 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (325-421): 5.3e-15: 79.4: 24.74
+	Hs
		983379 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Hs
		983403 DYN1_HUMAN (1-846): 0: 1002: 79.04		FNBP1_HUMAN (214-421): 7.83e-12: 69: 13.46