HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: PACN2 (Q9UNF0)
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
Gene: PACSIN2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	19041431, 16551695
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 486
+	Mm
		760487 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN2_MOUSE (1-486): 2.43e-101: 314: 93.83
+	Hs
		840812 DYN2_HUMAN (1-870): 0: 1057: 100.00		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Mm
		760475 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN1_MOUSE (1-485): 5.4e-81: 260: 61.24
+	Hs
		983417 DYN1_HUMAN (1-846): 0: 1002: 79.04		PACN2_HUMAN (1-486): 1.94e-100: 311: 100.00
+	Mm
		760485 DYN2_MOUSE (1-870): 0: 1057: 98.16		PACN3_MOUSE (6-485): 3.11e-69: 228: 43.54
+	Hs
		840860 DYN2_HUMAN (1-870): 0: 1057: 100.00		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		983406 DYN1_HUMAN (1-846): 0: 1002: 79.04		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Mm
		760451 DYN1_MOUSE (1-844): 0: 1003: 79.23		PACN1_MOUSE (1-485): 5.4e-81: 260: 61.24
+	Hs
		207784 DYN2_HUMAN (1-870): 0: 1057: 100.00		PPIP1_HUMAN (9-485): 2.02e-55: 192: 18.67
+	Hs
		840753 DYN2_HUMAN (1-870): 0: 1057: 100.00		FCSD1_HUMAN (26-481): 9.28e-47: 174: 14.79
+	Hs
		840700 DYN2_HUMAN (1-870): 0: 1057: 100.00		CIP4_HUMAN (12-465): 9.47e-47: 173: 15.03
+	Hs
		983416 DYN1_HUMAN (1-846): 0: 1002: 79.04		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		840798 DYN2_HUMAN (1-870): 0: 1057: 100.00		FNBP1_HUMAN (12-397): 7.86e-42: 159: 15.01
+	Mm
		760473 DYN2_MOUSE (1-870): 0: 1057: 98.16		SRC8_MOUSE (47-484): 1.33e-40: 154: 12.17
+	Hs
		840683 DYN2_HUMAN (1-870): 0: 1057: 100.00		MYO1E_HUMAN (9-485): 6.43e-38: 149: 13.04
+	Hs
		840692 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRC8_HUMAN (47-484): 5.84e-38: 147: 11.40
+	Hs
		983392 DYN1_HUMAN (1-846): 0: 1002: 79.04		NOSTN_HUMAN (24-485): 3.12e-47: 172: 16.13
+	Hs
		983403 DYN1_HUMAN (1-846): 0: 1002: 79.04		FNBP1_HUMAN (12-397): 7.86e-42: 159: 15.01
+	Hs
		983372 DYN1_HUMAN (1-846): 0: 1002: 79.04		MYO1E_HUMAN (9-485): 6.43e-38: 149: 13.04
+	Hs
		840723 DYN2_HUMAN (1-870): 0: 1057: 100.00		FBP1L_HUMAN (300-482): 7.32e-09: 60.2: 19.05