HitPredict

Interactor 1: TOB1 (P50616)
Protein Tob1 (Transducer of erbB-2 1)
Gene: TOB1

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11163184
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 345 Hs			1 465
+	Hs
		841398 TOB1_HUMAN (1-345): 4.62e-165: 465: 100.00		SMAD5_HUMAN (2-465): 0: 619: 89.46
+	Hs
		171372 TOB1_HUMAN (1-345): 4.62e-165: 465: 100.00		SMAD9_HUMAN (3-465): 0: 607: 81.29
+	Hs
		841379 TOB1_HUMAN (1-345): 4.62e-165: 465: 100.00		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Dr
		1186359 Q7SZP8_DANRE (1-345): 1.19e-153: 436: 74.86		Q8AY15_DANRE (5-465): 0: 559: 60.35
+	Dr
		1186360 Q7SZP8_DANRE (1-345): 1.19e-153: 436: 74.86		Q8AY16_DANRE (5-465): 0: 551: 59.27
+	Dr
		1186362 Q7SZR1_DANRE (1-345): 1.62e-141: 405: 78.74		Q8AY15_DANRE (5-465): 0: 559: 60.35
+	Dr
		1186363 Q7SZR1_DANRE (1-345): 1.62e-141: 405: 78.74		Q8AY16_DANRE (5-465): 0: 551: 59.27
+	Hs
		841384 TOB1_HUMAN (1-345): 4.62e-165: 465: 100.00		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Dm
		60229 A4V4L0_DROME (1-313): 2.45e-99: 305: 39.00		MAD_DROME (2-465): 0: 594: 72.85
+	Mm
		936604 BTG2_MOUSE (1-115): 3.28e-54: 177: 41.88		SMAD1_MOUSE (1-465): 0: 656: 99.14
+	Mm
		978996 BTG2_MOUSE (1-115): 3.28e-54: 177: 41.88		SMAD9_MOUSE (3-465): 0: 575: 76.51