HitPredict

Interactor 1: RORG (P51449)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Gene: RORC

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20203100
Identification Methods	amplified luminescent proximity homogeneous assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 518 Hs			1 1441
+	Hs
		723179 RORA_HUMAN (6-516): 7.11e-126: 379: 47.95		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		1078516 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		130328 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		265870 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		126112 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Hs
		846420 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		BMAL2_HUMAN (4-482): 6.31e-105: 349: 18.79
+	Mm
		846435 RORG_MOUSE (1-518): 1.51e-142: 422: 88.61		HIF1A_MOUSE (8-756): 1.16e-106: 361: 12.99
+	Hs
		723182 RORA_HUMAN (6-516): 7.11e-126: 379: 47.95		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Hs
		846431 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		181506 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Mm
		985522 RORB_MOUSE (13-509): 3.01e-124: 373: 44.69		Q05BA5_MOUSE (1-1411): 1.11e-76: 282: 23.77
+	Hs
		181531 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Mm
		60493 RORB_MOUSE (13-509): 3.01e-124: 373: 44.69		A5D6Q2_MOUSE (48-1411): 3.96e-70: 261: 22.54
+	Dm
		247694 E78C_DROME (30-515): 8.17e-90: 295: 24.16		CYCL_DROME (3-364): 1.39e-101: 333: 18.90
+	Hs
		181523 NR1D2_HUMAN (1-488): 1.19e-106: 331: 28.54		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Hs
		130340 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		265886 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		846423 RORG_HUMAN (1-518): 1.29e-153: 450: 100.00		NPAS2_HUMAN (29-210): 2.08e-09: 64.3: 29.73
+	Hs
		130327 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		265869 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43