HitPredict

Interactor 1: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031072 - heat shock protein binding and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 712 Hs			1 459
+	Hs
		848362 IRAK1_HUMAN (1-712): 0: 597: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		1035072 IRAK3_HUMAN (1-667): 4.27e-128: 394: 24.12		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		118711 IRAK1_HUMAN (1-712): 0: 597: 100.00		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		848370 IRAK1_HUMAN (1-712): 0: 597: 100.00		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		684539 IRAK1_HUMAN (1-712): 0: 597: 100.00		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51