Protein: TSYL2
Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79)

Gene: TSYL2, TSPYL2
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9H2G4

Gene Ontology (top 5):
GO:0000182 - rDNA binding
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1430539

TSYL1
Testis-specific Y-encoded-like protein 1

5

17

High-throughput

0.926

High

1330833

TSYL6
Testis-specific Y-encoded-like protein 6

4

15

High-throughput

0.900

High

1029384

SET
Protein SET

2

14

High-throughput

0.811

High

625619

CSK22
Casein kinase II subunit alpha'

4

18

High-throughput

0.699

High

998016

CSK21
Casein kinase II subunit alpha

4

20

High-throughput

0.698

High

1431850

NOP53
Ribosome biogenesis protein NOP53

4

1

High-throughput

0.698

High

1323538

ZN687
Zinc finger protein 687

4

3

High-throughput

0.692

High

1431856

ABT1
Activator of basal transcription 1

3

1

High-throughput

0.665

High

1232784

Q6FI91
TSPYL protein

1

15

High-throughput

0.665

High

1431859

U3KQK0
Histone H2B

1

20

High-throughput

0.665

High

1431855

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

3

6

High-throughput

0.656

High

1395481

ZFP91
E3 ubiquitin-protein ligase ZFP91

3

8

Small-scale

0.653

High

998797

H31
Histone H3.1

1

20

Small-scale

0.647

High

546997

FGF3
Fibroblast growth factor 3

2

2

High-throughput

0.628

High

612782

RL7
Large ribosomal subunit protein uL30

2

3

High-throughput

0.628

High

1037639

RL18A
Large ribosomal subunit protein eL20

2

1

High-throughput

0.628

High

1230900

Z324B
Zinc finger protein 324B

2

3

High-throughput

0.628

High

1415800

MAD3
Max dimerization protein 3

2

8

High-throughput

0.628

High

1368480

CBP
CREB-binding protein

1

14

Small-scale

0.621

High

1407997

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.621

High

208898

ZBT24
Zinc finger and BTB domain-containing protein 24

2

7

High-throughput

0.606

High

517703

ZBT48
Zinc finger and BTB domain-containing protein 48

2

4

High-throughput

0.606

High

681924

RBTN2
Rhombotin-2

2

2

High-throughput

0.606

High

1178086

RN151
RING finger protein 151

2

8

High-throughput

0.606

High

1241442

ZFP1
Zinc finger protein 1 homolog

2

4

High-throughput

0.606

High

1252567

AEBP2
Zinc finger protein AEBP2

2

4

High-throughput

0.606

High

1288139

ZN329
Zinc finger protein 329

2

2

High-throughput

0.606

High

1336373

Z280C
Zinc finger protein 280C

2

5

High-throughput

0.606

High

1348497

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

1385084

ZN775
Zinc finger protein 775

2

5

High-throughput

0.606

High

1385563

ZN524
Zinc finger protein 524

2

7

High-throughput

0.606

High

1431847

Z286A
Zinc finger protein 286A

2

2

High-throughput

0.606

High

1431857

ZN835
Zinc finger protein 835

2

4

High-throughput

0.606

High

848349

MAGA4
Melanoma-associated antigen 4

2

8

High-throughput

0.601

High

995260

CSK2B
Casein kinase II subunit beta

2

2

High-throughput

0.601

High

1155758

EZH2
Histone-lysine N-methyltransferase EZH2

2

3

Small-scale

0.595

High

1329866

SIR6
NAD-dependent protein deacylase sirtuin-6

2

6

Small-scale

0.586

High

983052

RS25
Small ribosomal subunit protein eS25

2

0

High-throughput

0.580

High

1194051

KMT5B
Histone-lysine N-methyltransferase KMT5B

2

0

High-throughput

0.580

High

1213587

PHF19
PHD finger protein 19

2

0

High-throughput

0.580

High

1346926

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.580

High

1389961

TMA16
Translation machinery-associated protein 16

2

0

High-throughput

0.580

High

1390161

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1397107

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.580

High

1403280

RBM15
RNA-binding protein 15

2

0

High-throughput

0.580

High

1420608

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1431854

NOL12
Nucleolar protein 12

2

0

High-throughput

0.580

High

1290718

ZCH18
Zinc finger CCCH domain-containing protein 18

2

5

High-throughput

0.574

High

573889

CCNB1
G2/mitotic-specific cyclin-B1

1

4

Small-scale

0.561

High

1431853

HMGX4
HMG domain-containing protein 4

2

7

High-throughput

0.553

High

1348956

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.549

High

1116008

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.541

High

287131

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

2

High-throughput

0.536

High

428974

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

517817

GLI4
Zinc finger protein GLI4

1

6

High-throughput

0.536

High

686421

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

785445

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

833777

KDM5C
Lysine-specific demethylase 5C

1

5

High-throughput

0.536

High

859067

RL27A
Large ribosomal subunit protein uL15

1

3

High-throughput

0.536

High

960885

RL15
Large ribosomal subunit protein eL15

1

6

High-throughput

0.536

High

970102

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1245496

CC137
Coiled-coil domain-containing protein 137

1

1

High-throughput

0.536

High

1281470

ZN467
Zinc finger protein 467

1

6

High-throughput

0.536

High

1431858

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.536

High

168746

CSKP
Peripheral plasma membrane protein CASK

1

0

Small-scale

0.529

High

1428535

DDX24
ATP-dependent RNA helicase DDX24

1

6

High-throughput

0.515

High

340405

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.513

High

800096

COIL
Coilin

1

1

High-throughput

0.508

High

1217763

GFI1B
Zinc finger protein Gfi-1b

1

8

High-throughput

0.508

High

176088

KDM6B
Lysine-specific demethylase 6B

1

1

Small-scale

0.501

High

194611

KDM6A
Lysine-specific demethylase 6A

1

5

Small-scale

0.501

High

443515

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.501

High

549237

CDK4
Cyclin-dependent kinase 4

1

8

Small-scale

0.501

High

668025

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.501

High

862448

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.501

High

1356136

THAP3
THAP domain-containing protein 3

1

1

High-throughput

0.489

High

1275337

APTX
Aprataxin

1

0

High-throughput

0.486

High

325501

CCNB2
G2/mitotic-specific cyclin-B2

1

4

Small-scale

0.479

High

342318

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

404408

GCR
Glucocorticoid receptor

1

11

High-throughput

0.479

High

485411

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

5

High-throughput

0.479

High

504973

H2AB2
Histone H2A-Bbd type 2/3

1

15

High-throughput

0.479

High

650955

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

High-throughput

0.479

High

674327

BRD2
Bromodomain-containing protein 2

1

18

High-throughput

0.479

High

714417

PML
Protein PML

1

6

High-throughput

0.479

High

831412

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

909693

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

5

High-throughput

0.479

High

960559

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.479

High

1114273

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1141302

BRD3
Bromodomain-containing protein 3

1

17

High-throughput

0.479

High

1153905

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.479

High

1181544

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

5

High-throughput

0.479

High

1338955

NUP43
Nucleoporin Nup43

1

6

High-throughput

0.479

High

1352745

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

211047

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

Small-scale

0.458

High

1160891

TBR1
T-box brain protein 1

1

0

Small-scale

0.458

High

1056968

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

877226

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.445

High

1110069

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.445

High

1314052

YAF2
YY1-associated factor 2

1

1

High-throughput

0.445

High

1288181

TBC26
TBC1 domain family member 26

1

1

High-throughput

0.439

High

1239937

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1431849

SHCAF
SIN3-HDAC complex-associated factor

1

0

High-throughput

0.426

High

568588

TNNT1
Troponin T, slow skeletal muscle

2

0

High-throughput

0.316

High

1431848

XAGE1
X antigen family member 1

2

0

High-throughput

0.316

High

838507

GRIA2
Glutamate receptor 2

1

0

High-throughput

0.279

Low

1431852

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.279

Low

1431851

DYH2
Dynein axonemal heavy chain 2

1

0

High-throughput

0.249

Low

1385058

CC049
Putative uncharacterized protein C3orf49

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025