HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	17132228, 17183367
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 745
+	Hs
		895790 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		CUL2_HUMAN (1-745): 0: 840: 100.00
+	Hs
		849326 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		895791 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		849325 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		895792 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		919724 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1041136 UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94		CUL1_HUMAN (6-745): 0: 775: 36.24
+	Hs
		1043149 UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		1042304 UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1042223 UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		851812 UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		828994 UBE2A_HUMAN (2-144): 2.83e-70: 209: 40.56		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		896438 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Dm
		639393 UBCD1_DROME (1-147): 1.87e-81: 238: 89.12		CUL1_DROME (6-745): 0: 726: 33.25
+	At
		1228143 COP10_ARATH (4-146): 1.14e-54: 171: 53.15		CUL4_ARATH (4-745): 0: 720: 26.60
+	Sp
		804458 UBC4_SCHPO (1-147): 6.75e-80: 234: 79.59		CUL3_SCHPO (8-745): 0: 620: 23.84