HitPredict

Interactor 1: CLCN3 (P51790)
H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)
Gene: CLCN3

Interactor 2: TMEM9 (Q9P0T7)
Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9)
Gene: TMEM9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005770 - late endosome GO:0043231 - intracellular membrane-bounded organelle GO:0048388 - endosomal lumen acidification
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 818 Hs			1 183
+	Hs
		850332 CLCN3_HUMAN (1-818): 0: 969: 100.00		TMM9B_HUMAN (19-183): 1.27e-78: 234: 60.48
+	Hs
		850350 CLCN5_HUMAN (8-818): 0: 876: 73.49		TMEM9_HUMAN (1-183): 1.16e-100: 289: 100.00
+	Hs
		850343 CLCN4_HUMAN (59-818): 0: 864: 78.16		TMEM9_HUMAN (1-183): 1.16e-100: 289: 100.00
+	Hs
		850349 CLCN5_HUMAN (8-818): 0: 876: 73.49		TMM9B_HUMAN (19-183): 1.27e-78: 234: 60.48
+	Hs
		850342 CLCN4_HUMAN (59-818): 0: 864: 78.16		TMM9B_HUMAN (19-183): 1.27e-78: 234: 60.48
+	Dm
		1214879 Q8IQN2_DROME (75-818): 0: 796: 62.50		Y1161_DROME (30-183): 1.79e-56: 179: 34.42