Protein: UBP6
Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)

Gene: UBP6
Organism: Saccharomyces cerevisiae S288C
Interactions: 133
UniProt ID: P43593

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005838 - proteasome regulatory particle
GO:0016579 - protein deubiquitination
GO:0032434 - regulation of proteasomal ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750967

PRS7
26S proteasome regulatory subunit 7 homolog

8

17

Small-scale

0.967

High

750859

PRS6B
26S proteasome regulatory subunit 6B homolog

6

12

High-throughput

0.945

High

850335

PRS8
26S proteasome regulatory subunit 8 homolog

5

15

Small-scale

0.925

High

822412

PRS4
26S proteasome regulatory subunit 4 homolog

4

14

High-throughput

0.896

High

850327

PRS10
26S proteasome subunit RPT4

4

17

High-throughput

0.896

High

750710

PRS6A
26S proteasome regulatory subunit 6A

3

13

High-throughput

0.839

High

509608

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

4

20

Small-scale

0.801

High

850314

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

17

High-throughput

0.776

High

850058

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

22

15

Small-scale

0.765

High

803594

RPN1
26S proteasome regulatory subunit RPN1

13

8

Small-scale

0.760

High

850324

RPN14
26S proteasome regulatory subunit RPN14

2

20

High-throughput

0.737

High

806749

RPN10
26S proteasome regulatory subunit RPN10

5

5

Small-scale

0.716

High

850349

RPN9
26S proteasome regulatory subunit RPN9

5

3

High-throughput

0.716

High

850355

RPN8
26S proteasome regulatory subunit RPN8

5

7

High-throughput

0.716

High

740184

RPN2
26S proteasome regulatory subunit RPN2

5

8

High-throughput

0.714

High

850360

RPN5
26S proteasome regulatory subunit RPN5

5

5

Small-scale

0.714

High

817068

RPN3
26S proteasome regulatory subunit RPN3

4

3

High-throughput

0.694

High

850361

RPN6
26S proteasome regulatory subunit RPN6

4

3

High-throughput

0.694

High

803144

ECM29
Proteasome component ECM29

4

8

Small-scale

0.687

High

645182

PSB4
Proteasome subunit beta type-4

4

15

Small-scale

0.676

High

850334

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

18

High-throughput

0.665

High

821973

PSA6
Proteasome subunit alpha type-6

3

12

High-throughput

0.662

High

850350

RPN7
26S proteasome regulatory subunit RPN7

3

4

High-throughput

0.657

High

743996

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.618

High

850331

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

17

Small-scale

0.618

High

738323

RPN12
26S proteasome regulatory subunit RPN12

2

1

High-throughput

0.601

High

850351

CORO
Coronin-like protein

1

19

High-throughput

0.595

High

661535

PSA2
Proteasome subunit alpha type-2

2

10

High-throughput

0.584

High

150292

RPN13
26S proteasome regulatory subunit RPN13

2

0

High-throughput

0.576

High

314882

SEM1
26S proteasome complex subunit SEM1

2

0

High-throughput

0.576

High

524323

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.536

High

850320

PSD10
Probable 26S proteasome regulatory subunit p28

2

17

High-throughput

0.521

High

526991

HSP72
Heat shock protein SSA2

2

12

High-throughput

0.504

High

850352

ERFB
Palmitoyltransferase ERF2

1

1

High-throughput

0.494

High

636595

PSA7
Probable proteasome subunit alpha type-7

1

13

High-throughput

0.479

High

636675

PSA1
Proteasome subunit alpha type-1

1

13

High-throughput

0.479

High

661420

PSA3
Proteasome subunit alpha type-3

1

12

High-throughput

0.479

High

662052

PSB6
Proteasome subunit beta type-6

1

17

High-throughput

0.479

High

668399

PSB2
Proteasome subunit beta type-2

1

12

High-throughput

0.479

High

670855

SIS1
Protein SIS1

1

8

High-throughput

0.479

High

675255

PSB3
Proteasome subunit beta type-3

1

13

High-throughput

0.479

High

721320

PSB7
Proteasome subunit beta type-7

1

16

High-throughput

0.479

High

735940

PSA5
Proteasome subunit alpha type-5

1

9

High-throughput

0.479

High

800853

PSB1
Proteasome subunit beta type-1

1

16

High-throughput

0.479

High

822007

PSA4
Proteasome subunit alpha type-4

1

11

High-throughput

0.479

High

677889

DPO4
DNA polymerase IV

1

1

High-throughput

0.470

High

703775

CAPZA
F-actin-capping protein subunit alpha

1

3

High-throughput

0.470

High

762838

TOR1
Serine/threonine-protein kinase TOR1

1

12

High-throughput

0.470

High

814219

RV167
Reduced viability upon starvation protein 167

1

3

High-throughput

0.470

High

850356

MDN1
Midasin

1

20

High-throughput

0.470

High

850358

YRA1
RNA annealing protein YRA1

1

7

High-throughput

0.470

High

850362

AIR2
Protein AIR2

1

2

High-throughput

0.470

High

850332

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

441171

KAPA
cAMP-dependent protein kinase type 1

1

9

High-throughput

0.457

High

448750

SNF1
Carbon catabolite-derepressing protein kinase

1

12

High-throughput

0.457

High

560721

KIN2
Serine/threonine-protein kinase KIN2

1

18

High-throughput

0.457

High

584370

GCN2
eIF-2-alpha kinase GCN2

1

9

High-throughput

0.457

High

602526

PHO85
Cyclin-dependent protein kinase PHO85

1

9

High-throughput

0.457

High

656513

KC11
Casein kinase I homolog 1

1

11

High-throughput

0.457

High

667060

CG21
G2/mitotic-specific cyclin-1

1

4

Small-scale

0.457

High

667100

CG22
G2/mitotic-specific cyclin-2

1

4

Small-scale

0.457

High

692382

KCC1
Calcium/calmodulin-dependent protein kinase I

1

3

High-throughput

0.457

High

850321

ATG1
Serine/threonine-protein kinase ATG1

1

15

High-throughput

0.457

High

850343

SKY1
Serine/threonine-protein kinase SKY1

1

20

High-throughput

0.457

High

850345

VHS1
Serine/threonine-protein kinase VHS1

1

7

High-throughput

0.457

High

850322

HUL5
E3 ubiquitin-protein ligase HUL5

1

20

Small-scale

0.445

High

392924

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.437

High

531550

RT02
Small ribosomal subunit protein uS14m

1

1

High-throughput

0.437

High

579605

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.437

High

594431

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

705647

HIBCH
Small ribosomal subunit protein mS47

1

7

High-throughput

0.437

High

740970

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

8

High-throughput

0.437

High

747131

RT04
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.437

High

754482

RT05
Small ribosomal subunit protein uS5m

1

5

High-throughput

0.437

High

793793

RT09
Small ribosomal subunit protein uS9m

1

3

High-throughput

0.437

High

850318

RT26
Small ribosomal subunit protein mS42

1

2

High-throughput

0.437

High

850319

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.437

High

850328

RT12
Small ribosomal subunit protein uS12m

1

3

High-throughput

0.437

High

850329

RT19
Small ribosomal subunit protein uS19m

1

1

High-throughput

0.437

High

850337

ULP1
Ubiquitin-like-specific protease 1

1

9

High-throughput

0.437

High

850339

ESP1
Separin

1

3

High-throughput

0.437

High

850340

RT10
Small ribosomal subunit protein uS10m

1

3

High-throughput

0.437

High

850344

ESC1
Silent chromatin protein ESC1

1

2

High-throughput

0.437

High

850359

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.437

High

545311

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.407

High

671654

SCJ1
DnaJ-related protein SCJ1

1

10

High-throughput

0.407

High

676103

MAS5
Mitochondrial protein import protein MAS5

1

10

High-throughput

0.407

High

741821

HSP7F
Heat shock protein homolog SSE1

1

18

High-throughput

0.407

High

810835

TCPG
T-complex protein 1 subunit gamma

1

12

High-throughput

0.407

High

811339

CAJ1
Protein CAJ1

1

13

High-throughput

0.407

High

816267

HSP7E
Heat shock protein SSC3, mitochondrial

1

18

High-throughput

0.407

High

850353

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.407

High

820872

GAT2
Protein GAT2

1

0

High-throughput

0.282

High

850323

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.282

High

850354

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.282

High

757791

TOD6
Transcriptional regulatory protein TOD6

1

0

High-throughput

0.269

Low

850315

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.269

Low

822222

SECU
Securin

1

0

Small-scale

0.261

Low

268886

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

382936

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

531483

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.249

Low

554511

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

605387

RTPT
Small ribosomal subunit protein mS26

1

0

High-throughput

0.249

Low

640718

RT28
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.249

Low

699510

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.249

Low

705090

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.249

Low

735036

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

779998

POC2
Proteasome assembly chaperone 2

1

0

High-throughput

0.249

Low

780407

RT22
Ribosome assembly protein RSM22, mitochondrial

1

0

High-throughput

0.249

Low

794897

RT21
Small ribosomal subunit protein bS21m

1

0

High-throughput

0.249

Low

797532

UMP1
Proteasome maturation factor UMP1

1

0

High-throughput

0.249

Low

804044

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.249

Low

805822

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.249

Low

812419

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

817358

RSM18
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.249

Low

825501

RT25
Small ribosomal subunit protein mS23

1

0

High-throughput

0.249

Low

843297

RT18
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.249

Low

850317

AIM23
Altered inheritance of mitochondria protein 23, mitochondrial

1

0

High-throughput

0.249

Low

850325

RT35
Small ribosomal subunit protein mS45

1

0

High-throughput

0.249

Low

850326

RT27
Small ribosomal subunit protein mS33

1

0

High-throughput

0.249

Low

850330

CAF40
Protein CAF40

1

0

High-throughput

0.249

Low

850333

RT23
Small ribosomal subunit protein mS29

1

0

High-throughput

0.249

Low

850336

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.249

Low

850338

RT51
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.249

Low

850341

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.249

Low

850342

RSM28
Small ribosomal subunit protein mS46

1

0

High-throughput

0.249

Low

850346

RT08
Small ribosomal subunit protein uS8m

1

0

High-throughput

0.249

Low

850347

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

850348

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

850357

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

752412

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

850316

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025