Protein: PRS7
26S proteasome regulatory subunit 7 homolog (Protein CIM5) (Tat-binding homolog 3)

Gene: PRS7, RPT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 205
UniProt ID: P33299

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750966

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

31

20

Small-scale

0.992

High

750939

RPN1
26S proteasome regulatory subunit RPN1

25

20

Small-scale

0.991

High

750955

PRS4
26S proteasome regulatory subunit 4 homolog

17

20

Small-scale

0.988

High

750994

PRS8
26S proteasome regulatory subunit 8 homolog

19

20

Small-scale

0.987

High

750929

HSM3
DNA mismatch repair protein HSM3

14

2

Small-scale

0.986

High

750816

PRS6B
26S proteasome regulatory subunit 6B homolog

16

20

Small-scale

0.985

High

645148

PSB4
Proteasome subunit beta type-4

16

20

Small-scale

0.982

High

750607

PRS6A
26S proteasome regulatory subunit 6A

14

20

Small-scale

0.982

High

750975

PSD10
Probable 26S proteasome regulatory subunit p28

13

13

Small-scale

0.981

High

743968

RAD23
UV excision repair protein RAD23

11

20

Small-scale

0.980

High

750982

PRS10
26S proteasome subunit RPT4

12

20

Small-scale

0.978

High

750967

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

8

17

Small-scale

0.967

High

751017

RPN8
26S proteasome regulatory subunit RPN8

8

20

Small-scale

0.965

High

751007

RPN7
26S proteasome regulatory subunit RPN7

7

20

Small-scale

0.962

High

751020

RPN5
26S proteasome regulatory subunit RPN5

7

20

Small-scale

0.962

High

750972

DSK2
Ubiquitin domain-containing protein DSK2

5

20

Small-scale

0.927

High

750953

PSA4
Proteasome subunit alpha type-4

4

20

Small-scale

0.886

High

750933

PSB1
Proteasome subunit beta type-1

3

20

Small-scale

0.847

High

509472

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

20

Small-scale

0.834

High

735915

PSA5
Proteasome subunit alpha type-5

3

20

Small-scale

0.827

High

479260

CDC6
Cell division control protein 6

2

0

High-throughput

0.761

High

740130

RPN2
26S proteasome regulatory subunit RPN2

12

20

Small-scale

0.756

High

750979

RPN14
26S proteasome regulatory subunit RPN14

10

19

Small-scale

0.756

High

636560

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.754

High

636647

PSA1
Proteasome subunit alpha type-1

2

20

Small-scale

0.754

High

661394

PSA3
Proteasome subunit alpha type-3

2

20

High-throughput

0.754

High

661489

PSA2
Proteasome subunit alpha type-2

2

20

High-throughput

0.754

High

668378

PSB2
Proteasome subunit beta type-2

2

20

Small-scale

0.754

High

679530

CDC48
Cell division control protein 48

2

20

Small-scale

0.754

High

750916

PRS7
26S proteasome regulatory subunit 7 homolog

2

18

Small-scale

0.754

High

750952

PSA6
Proteasome subunit alpha type-6

2

20

High-throughput

0.754

High

750942

RPN10
26S proteasome regulatory subunit RPN10

10

13

Small-scale

0.753

High

738292

RPN12
26S proteasome regulatory subunit RPN12

9

8

Small-scale

0.752

High

751022

RPN6
26S proteasome regulatory subunit RPN6

8

20

Small-scale

0.747

High

150279

RPN13
26S proteasome regulatory subunit RPN13

7

3

Small-scale

0.744

High

751004

RPN9
26S proteasome regulatory subunit RPN9

6

14

Small-scale

0.729

High

750950

RPN3
26S proteasome regulatory subunit RPN3

5

14

Small-scale

0.712

High

314860

SEM1
26S proteasome complex subunit SEM1

5

2

Small-scale

0.709

High

750938

ECM29
Proteasome component ECM29

4

14

High-throughput

0.691

High

523482

HSP71
Heat shock protein SSA1

3

14

Small-scale

0.640

High

750958

PSMD9
Probable 26S proteasome regulatory subunit p27

1

9

Small-scale

0.621

High

616408

SEC18
Vesicular-fusion protein SEC18

1

20

High-throughput

0.618

High

662031

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.618

High

675237

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

721247

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.618

High

721297

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

726892

HS104
Heat shock protein 104

1

8

High-throughput

0.618

High

750992

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

12

Small-scale

0.618

High

364443

CDK1
Cyclin-dependent kinase 1

2

8

Small-scale

0.601

High

561454

TBP
TATA-box-binding protein

2

5

Small-scale

0.585

High

579115

HSC82
ATP-dependent molecular chaperone HSC82

2

13

High-throughput

0.584

High

670527

SIS1
Protein SIS1

2

12

High-throughput

0.584

High

750925

UMP1
Proteasome maturation factor UMP1

2

1

Small-scale

0.584

High

750999

RPN4
Protein RPN4

2

1

Small-scale

0.584

High

740486

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

12

Small-scale

0.575

High

751012

RIX7
Ribosome biogenesis ATPase RIX7

1

20

High-throughput

0.575

High

526282

HSP72
Heat shock protein SSA2

2

16

Small-scale

0.571

High

554409

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

2

3

Small-scale

0.571

High

751025

RUVB2
RuvB-like protein 2

2

9

High-throughput

0.571

High

445330

CDC31
Cell division control protein 31

1

8

Small-scale

0.561

High

454427

PHO4
Phosphate system positive regulatory protein PHO4

1

2

Small-scale

0.561

High

625952

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

Small-scale

0.561

High

750977

RTF1
RNA polymerase-associated protein RTF1

1

1

Small-scale

0.561

High

668256

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.546

High

748314

SC61A
Protein transport protein SEC61

2

6

Small-scale

0.543

High

471393

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

2

High-throughput

0.536

High

721804

XPO1
Exportin-1

1

8

High-throughput

0.536

High

739943

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

7

Small-scale

0.536

High

750963

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.536

High

750981

BUD32
EKC/KEOPS complex subunit BUD32

1

2

High-throughput

0.536

High

751026

YO098
Uncharacterized protein YOL098C

1

1

High-throughput

0.536

High

751000

ESC1
Silent chromatin protein ESC1

2

6

High-throughput

0.533

High

747261

RSSA1
Small ribosomal subunit protein uS2A

2

4

High-throughput

0.521

High

750930

PAF1
RNA polymerase II-associated protein 1

1

1

Small-scale

0.515

High

750932

LEO1
RNA polymerase-associated protein LEO1

1

2

Small-scale

0.515

High

750991

CTR9
RNA polymerase-associated protein CTR9

1

7

Small-scale

0.515

High

750940

CIC1
Proteasome-interacting protein CIC1

1

0

Small-scale

0.513

High

751015

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

Small-scale

0.513

High

408404

GAL4
Regulatory protein GAL4

1

2

Small-scale

0.501

High

750928

ATG12
Ubiquitin-like protein ATG12

1

2

High-throughput

0.489

High

750968

RSSA2
Small ribosomal subunit protein uS2B

1

4

High-throughput

0.489

High

633245

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

Small-scale

0.480

High

149672

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

392483

HSP82
ATP-dependent molecular chaperone HSP82

1

13

High-throughput

0.479

High

394406

EF1A
Elongation factor 1-alpha

1

5

Small-scale

0.479

High

434966

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

486767

CDC16
Anaphase-promoting complex subunit CDC16

1

10

Small-scale

0.479

High

597092

BIP
Endoplasmic reticulum chaperone BiP

1

11

Small-scale

0.479

High

603033

EST1
Telomere elongation protein EST1

1

2

High-throughput

0.479

High

647071

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

5

High-throughput

0.479

High

667080

CG22
G2/mitotic-specific cyclin-2

1

2

Small-scale

0.479

High

674517

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

678941

NOT1
General negative regulator of transcription subunit 1

1

2

Small-scale

0.479

High

706640

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

734912

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

737813

HOG1
Mitogen-activated protein kinase HOG1

1

9

High-throughput

0.479

High

738801

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

741263

HSP7F
Heat shock protein homolog SSE1

1

20

Small-scale

0.479

High

747778

SMY2
Protein SMY2

1

3

High-throughput

0.479

High

750921

RS27A
Small ribosomal subunit protein eS27A

1

5

High-throughput

0.479

High

750922

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.479

High

750923

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.479

High

750924

GBLP
Small ribosomal subunit protein RACK1

1

16

High-throughput

0.479

High

750926

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

750935

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

750941

WSS1
DNA-dependent metalloprotease WSS1

1

2

Small-scale

0.479

High

750948

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

5

High-throughput

0.479

High

750949

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

4

High-throughput

0.479

High

750959

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.479

High

750965

BLM10
Proteasome activator BLM10

1

5

High-throughput

0.479

High

750969

MPS3
Spindle pole body assembly component MPS3

1

3

High-throughput

0.479

High

750971

MOG1
Nuclear import protein MOG1

1

2

High-throughput

0.479

High

750973

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

750974

VATG
V-type proton ATPase subunit G

1

3

High-throughput

0.479

High

750978

INO80
Chromatin-remodeling ATPase INO80

1

8

Small-scale

0.479

High

750984

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

12

High-throughput

0.479

High

750986

APJ1
J domain-containing protein APJ1

1

12

High-throughput

0.479

High

750988

UBX4
UBX domain-containing protein 4

1

1

Small-scale

0.479

High

750990

H3
Histone H3

1

9

High-throughput

0.479

High

750993

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

750995

PNG1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

2

Small-scale

0.479

High

750997

ESP1
Separin

1

1

High-throughput

0.479

High

750998

TOM1
E3 ubiquitin-protein ligase TOM1

1

13

High-throughput

0.479

High

751002

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

3

High-throughput

0.479

High

751003

RUVB1
RuvB-like protein 1

1

9

High-throughput

0.479

High

751006

POC1
Proteasome chaperone 1

1

1

High-throughput

0.479

High

751008

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

751009

TFC6
Transcription factor tau 91 kDa subunit

1

3

High-throughput

0.479

High

751010

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.479

High

751011

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.479

High

751013

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

15

Small-scale

0.479

High

751014

CUE5
Ubiquitin-binding protein CUE5

1

1

Small-scale

0.479

High

751016

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.479

High

751023

DBP10
ATP-dependent RNA helicase DBP10

1

14

High-throughput

0.479

High

750920

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

750934

STS1
Tethering factor for nuclear proteasome STS1

1

0

Small-scale

0.458

High

751001

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

751021

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

416217

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

11

High-throughput

0.445

High

440925

CDC7
Cell division control protein 7

1

20

Small-scale

0.445

High

449327

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

1

High-throughput

0.445

High

544308

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

592140

VATB
V-type proton ATPase subunit B

1

8

High-throughput

0.445

High

617382

GBB
Guanine nucleotide-binding protein subunit beta

1

13

High-throughput

0.445

High

649482

UBA1
Ubiquitin-activating enzyme E1 1

1

4

High-throughput

0.445

High

675322

RAD51
DNA repair protein RAD51

1

1

High-throughput

0.445

High

692316

KCC1
Calcium/calmodulin-dependent protein kinase I

1

7

High-throughput

0.445

High

701682

URA7
CTP synthase 1

1

5

High-throughput

0.445

High

734644

IMB3
Importin subunit beta-3

1

9

High-throughput

0.445

High

736840

APE2
Aminopeptidase 2, mitochondrial

1

8

High-throughput

0.445

High

738357

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

3

High-throughput

0.445

High

740247

SMI1
Cell wall assembly regulator SMI1

1

1

High-throughput

0.445

High

750936

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.445

High

750944

TCPD
T-complex protein 1 subunit delta

1

13

High-throughput

0.445

High

750945

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.445

High

750951

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

750960

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.445

High

750970

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.445

High

751005

PDR15
ATP-dependent permease PDR15

1

2

High-throughput

0.445

High

751024

AHA1
Hsp90 co-chaperone AHA1

1

5

High-throughput

0.445

High

750985

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

383606

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.437

High

410029

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.437

High

433547

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.437

High

441811

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.437

High

454967

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.437

High

502945

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.437

High

504129

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.437

High

512347

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.437

High

512913

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

577077

SEC63
Protein translocation protein SEC63

1

2

Small-scale

0.437

High

597606

CDC23
Anaphase-promoting complex subunit CDC23

1

9

Small-scale

0.437

High

677332

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

679041

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.437

High

750918

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.437

High

750937

GOSR1
Golgi SNAP receptor complex member 1

1

2

High-throughput

0.437

High

750946

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

750954

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

3

Small-scale

0.437

High

750957

MLP2
Protein MLP2

1

8

High-throughput

0.437

High

750964

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.437

High

750976

SC6B1
Protein transport protein SBH1

1

1

Small-scale

0.437

High

751018

RS10A
Small ribosomal subunit protein eS10A

1

8

High-throughput

0.437

High

751027

OS9
Protein OS-9 homolog

1

1

Small-scale

0.437

High

631879

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.426

High

750956

DLS1
Protein DLS1

1

0

High-throughput

0.426

High

750980

RAGCD
GTP-binding protein GTR2

1

0

High-throughput

0.426

High

456376

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

4

High-throughput

0.407

High

554326

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

3

High-throughput

0.407

High

703797

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.407

High

738622

EI2BB
Translation initiation factor eIF2B subunit beta

1

4

High-throughput

0.407

High

750917

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

5

High-throughput

0.407

High

750943

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

6

High-throughput

0.407

High

750961

VATH
V-type proton ATPase subunit H

1

2

High-throughput

0.407

High

750962

COPB
Coatomer subunit beta

1

8

High-throughput

0.407

High

750983

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.407

High

750987

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.407

High

750989

TMEDA
Endoplasmic reticulum vesicle protein 25

1

4

High-throughput

0.407

High

751019

FSF1
Sideroflexin FSF1

1

2

High-throughput

0.407

High

750996

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

0

Small-scale

0.261

Low

641359

SEC62
Translocation protein SEC62

1

0

Small-scale

0.249

Low

750919

SC61G
Protein transport protein SSS1

1

0

Small-scale

0.249

Low

750931

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

0

Small-scale

0.249

Low

750947

SEC72
Translocation protein SEC72

1

0

Small-scale

0.249

Low

750927

FTH1
Iron transporter FTH1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025