HitPredict

Interactor 1: PRKX (P51817)
cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)
Gene: PRKX

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 358 Hs			1 457
+	Hs
		217878 PRKY_HUMAN (1-272): 0: 506: 92.28		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		682173 AKT2_HUMAN (11-351): 7.4e-153: 440: 38.66		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035058 AKT3_HUMAN (7-355): 4.72e-152: 438: 37.78		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		681830 AKT1_HUMAN (11-351): 1.63e-150: 434: 37.68		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		568651 KAPCA_HUMAN (5-358): 8.26e-152: 432: 49.72		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		610723 KAPCB_HUMAN (5-358): 2.49e-151: 431: 49.72		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609666 KAPCG_HUMAN (38-358): 1.21e-149: 427: 46.73		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035034 KS6B2_HUMAN (6-358): 8.29e-146: 422: 34.07		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609664 KAPCG_HUMAN (38-358): 1.21e-149: 427: 46.73		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		1035006 SGK2_HUMAN (25-334): 1.23e-79: 249: 41.18		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		118712 PRKX_HUMAN (1-358): 5.47e-155: 441: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118692 KAPCG_HUMAN (38-358): 1.21e-149: 427: 46.73		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		568664 KAPCA_HUMAN (5-358): 8.26e-152: 432: 49.72		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		609671 KAPCG_HUMAN (38-358): 1.21e-149: 427: 46.73		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		1053243 KS6B2_HUMAN (6-358): 8.29e-146: 422: 34.07		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Rn
		193486 AKT3_RAT (7-349): 9.24e-150: 432: 37.86		STIP1_RAT (265-457): 1.25e-22: 102: 18.14
+	Hs
		609649 KAPCG_HUMAN (38-358): 1.21e-149: 427: 46.73		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		118793 SGK2_HUMAN (25-334): 1.23e-79: 249: 41.18		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72