HitPredict

Interactor 1: ARP2 (P45888)
Actin-related protein 2 (Actin-like protein 14D) (Actin-like protein 2)
Gene: ARP2

Interactor 2: CAPZA (Q9W2N0)
F-actin-capping protein subunit alpha
Gene: cpa

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~F-actin_cap_A
Common GO terms	GO:0003779 - actin binding GO:0007015 - actin filament organization GO:0051489 - regulation of filopodium assembly
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 399 Dm			1 286
+	Hs
		866633 ARP2_HUMAN (1-394): 0: 696: 81.47		CAZA2_HUMAN (6-284): 2.11e-151: 426: 61.65
+	Dm
		534516 ACT1_DROME (1-394): 0: 557: 45.69		CAPZA_DROME (1-286): 1.19e-150: 424: 100.00
+	Hs
		915051 ACTB_HUMAN (1-394): 0: 554: 46.45		CAZA1_HUMAN (6-284): 9.92e-152: 427: 64.52
+	Hs
		915061 ACTG_HUMAN (3-394): 0: 554: 46.17		CAZA1_HUMAN (6-284): 9.92e-152: 427: 64.52
+	Hs
		866631 ACTB_HUMAN (1-394): 0: 554: 46.45		CAZA2_HUMAN (6-284): 2.11e-151: 426: 61.65
+	Hs
		866640 ACTG_HUMAN (3-394): 0: 554: 46.17		CAZA2_HUMAN (6-284): 2.11e-151: 426: 61.65
+	Hs
		866643 ACTS_HUMAN (2-394): 0: 551: 46.06		CAZA2_HUMAN (6-284): 2.11e-151: 426: 61.65
+	Hs
		915062 ACTC_HUMAN (2-394): 0: 550: 46.57		CAZA1_HUMAN (6-284): 9.92e-152: 427: 64.52
+	Dm
		921009 ACT3_DROME (1-394): 0: 553: 45.18		CAPZA_DROME (1-286): 1.19e-150: 424: 100.00
+	Dm
		1014465 ACT6_DROME (1-394): 0: 552: 45.94		CAPZA_DROME (1-286): 1.19e-150: 424: 100.00
+	Hs
		866642 ACTC_HUMAN (2-394): 0: 550: 46.57		CAZA2_HUMAN (6-284): 2.11e-151: 426: 61.65