HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	35575683, 24981860, 33961781, 36089195, 29044188, 17403666, 19834512
Identification Methods	cross-linking study, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, nuclear magnetic resonance, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Chromo~Histone
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 136
+	Hs
		853220 CBX5_HUMAN (1-191): 1.25e-68: 209: 100.00		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Mm
		1017356 CBX5_MOUSE (1-191): 1.91e-68: 208: 97.91		H33_MOUSE (1-136): 1.13e-59: 182: 100.00
+	Hs
		853278 CBX5_HUMAN (1-191): 1.25e-68: 209: 100.00		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Hs
		853316 CBX5_HUMAN (1-191): 1.25e-68: 209: 100.00		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Mm
		1016758 CBX5_MOUSE (1-191): 1.91e-68: 208: 97.91		H32_MOUSE (1-136): 5.34e-59: 180: 97.06
+	Hs
		853304 CBX5_HUMAN (1-191): 1.25e-68: 209: 100.00		H3C_HUMAN (1-136): 2e-56: 173: 95.59
+	Hs
		998274 CBX3_HUMAN (1-181): 3.08e-62: 192: 60.22		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		1016822 CBX3_HUMAN (1-181): 3.08e-62: 192: 60.22		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Mm
		1017378 Q9DCC5_MOUSE (1-181): 3.08e-62: 192: 60.22		H33_MOUSE (1-136): 1.13e-59: 182: 100.00
+	Hs
		1097314 CBX3_HUMAN (1-181): 3.08e-62: 192: 60.22		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Mm
		1016771 Q9DCC5_MOUSE (1-181): 3.08e-62: 192: 60.22		H32_MOUSE (1-136): 5.34e-59: 180: 97.06
+	Hs
		1097377 CBX3_HUMAN (1-181): 3.08e-62: 192: 60.22		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Hs
		998210 CBX1_HUMAN (26-180): 2.33e-55: 175: 60.65		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Mm
		999019 CBX1_MOUSE (26-180): 2.33e-55: 175: 60.65		H31_MOUSE (1-136): 3.09e-60: 183: 96.32
+	Hs
		1014069 CBX1_HUMAN (26-180): 2.33e-55: 175: 60.65		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Hs
		1014111 CBX1_HUMAN (26-180): 2.33e-55: 175: 60.65		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Dm
		381747 Q9W396_DROME (19-175): 3.88e-55: 176: 50.96		H3_DROME (1-136): 5.34e-59: 180: 97.06
+	Hs
		1014137 CBX1_HUMAN (26-180): 2.33e-55: 175: 60.65		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Hs
		853196 CBX5_HUMAN (1-191): 1.25e-68: 209: 100.00		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76
+	Hs
		883528 CBX3_HUMAN (1-181): 3.08e-62: 192: 60.22		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76