HitPredict

Interactor 1: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Interactor 2: STAM1 (Q92783)
Signal transducing adapter molecule 1 (STAM-1)
Gene: STAM

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9133424
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1124 Hs			1 540
+	Hs
		277031 JAK3_HUMAN (1-1124): 0: 968: 100.00		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Mm
		936443 JAK2_MOUSE (4-1101): 0: 897: 48.38		STAM1_MOUSE (1-540): 2.94e-129: 389: 89.78
+	Hs
		238425 JAK2_HUMAN (7-1101): 0: 889: 47.80		STAM1_HUMAN (1-518): 1.32e-126: 382: 100.00
+	Hs
		238321 JAK2_HUMAN (7-1101): 0: 889: 47.80		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		238395 JAK2_HUMAN (7-1101): 0: 889: 47.80		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		277005 JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		272790 SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25		TM1L1_HUMAN (6-504): 8.91e-52: 185: 16.27
+	Hs
		272786 FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60		TM1L1_HUMAN (6-504): 8.91e-52: 185: 16.27
+	Hs
		272788 LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40		TM1L1_HUMAN (6-504): 8.91e-52: 185: 16.27
+	Hs
		275157 ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48		GRAP2_HUMAN (213-264): 2.75e-14: 75.9: 57.69
+	Hs
		789054 ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		337418 ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		522887 SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Mm
		763393 FYN_MOUSE (790-1109): 6.19e-97: 320: 29.60		GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90
+	Hs
		275197 ERBB4_HUMAN (822-1104): 2.36e-87: 310: 36.62		GRAP2_HUMAN (213-264): 2.75e-14: 75.9: 57.69
+	Hs
		924589 ERBB4_HUMAN (822-1104): 2.36e-87: 310: 36.62		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Ce
		220205 SRC2_CAEEL (780-1099): 2.29e-94: 312: 30.00		SEM5_CAEEL (204-264): 7.13e-12: 67: 44.26
+	Dm
		337676 SRC64_DROME (790-1105): 2.06e-90: 303: 28.84		GRAP_DROME (215-265): 4.5e-10: 61.6: 50.98
+	Mm
		972995 TIE2_MOUSE (813-1091): 4.05e-39: 160: 33.88		GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90
+	Hs
		616783 JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90