HitPredict

Interactor 1: RPAB3 (P52434)
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)
Gene: POLR2H

Interactor 2: RPB11 (P52435)
DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)
Gene: POLR2J

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	24981860, 35271311, 33961781, 17643375
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RNA_pol_L_2~RNA_pol_Rpb8
Common GO terms	GO:0001055 - RNA polymerase II activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005665 - RNA polymerase II, core complex GO:0006366 - transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 150 Hs			1 117
+	Hs
		484439 RPAB3_HUMAN (1-150): 1.61e-78: 231: 100.00		RPAC2_HUMAN (12-116): 3.57e-40: 131: 30.56
+	Sc
		593314 RPAB3_YEAST (1-147): 2.38e-48: 154: 35.07		RPB11_YEAST (1-110): 4.2e-45: 144: 50.00
+	Sc
		593289 RPAB3_YEAST (1-147): 2.38e-48: 154: 35.07		RPAC2_YEAST (13-110): 5.03e-33: 114: 33.33