Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL
Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.43 | 1.00 | 0.656 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 18654987 |
| Identification Methods | two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Ank_2~SH3_1 |
| Common GO terms | GO:0005654 - nucleoplasm GO:0010629 - negative regulation of gene expression GO:0035556 - intracellular signal transduction GO:0070374 - positive regulation of ERK1 and ERK2 cascade |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
