HitPredict

Interactor 1: EFNA5 (P52803)
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Gene: EFNA5

Interactor 2: EPHB1 (P54762)
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
Gene: EPHB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9245480
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0031290 - retinal ganglion cell axon guidance GO:0048013 - ephrin receptor signaling pathway GO:0051965 - positive regulation of synapse assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Hs			1 984
+	Mm
		139052 EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06		EPHB2_MOUSE (19-981): 0: 1199: 73.86
+	Mm
		139053 EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06		EPHA7_MOUSE (1-981): 0: 1153: 57.36
+	Hs
		856606 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA7_HUMAN (1-981): 0: 1151: 56.96
+	Hs
		856597 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA4_HUMAN (13-983): 0: 1150: 59.10
+	Dr
		945416 EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74		Q5ZEW1_DANRE (8-983): 0: 1178: 58.69
+	Hs
		856595 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA5_HUMAN (1-981): 0: 1143: 55.78
+	Hs
		665382 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA3_HUMAN (14-981): 0: 1131: 55.67
+	Mm
		139054 EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06		Q8BRB1_MOUSE (4-981): 0: 1118: 55.11
+	Hs
		665579 EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74		EPHB2_HUMAN (19-981): 0: 1198: 73.76
+	Dr
		47566 EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74		A0A8M9PHF0_DANRE (1-981): 0: 1132: 55.58
+	Hs
		856630 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA6_HUMAN (1-982): 0: 1098: 52.04
+	Dr
		140384 EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74		EPHA3_DANRE (3-976): 0: 1113: 54.14
+	Hs
		856319 EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79		EPHA7_HUMAN (1-981): 0: 1151: 56.96
+	Hs
		665459 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA8_HUMAN (19-981): 0: 1061: 51.78
+	Hs
		665379 EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79		EPHA3_HUMAN (14-981): 0: 1131: 55.67
+	Hs
		665390 EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74		EPHA3_HUMAN (14-981): 0: 1131: 55.67
+	Hs
		665181 EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00		EPHA2_HUMAN (17-978): 0: 1032: 46.58
+	Hs
		872403 EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74		EPHB3_HUMAN (16-979): 0: 1118: 70.56
+	Hs
		665179 EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79		EPHA2_HUMAN (17-978): 0: 1032: 46.58
+	Hs
		674396 EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74		UFO_HUMAN (131-963): 1.83e-174: 532: 23.30