HitPredict

Interactor 1: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32640226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 833
+	Hs
		930942 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		890991 PP4C_HUMAN (187-488): 7.07e-164: 467: 39.61		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		930913 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Rn
		858690 PPP5_RAT (1-499): 0: 572: 98.00		AKT3_RAT (10-325): 2.15e-125: 387: 25.31
+	Hs
		59883 Q9BPW0_HUMAN (3-483): 0: 544: 99.38		A4D2J9_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		930835 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		681777 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Mm
		682104 PP2AA_MOUSE (190-481): 7.01e-167: 475: 40.88		AKT1_MOUSE (1-337): 5.84e-129: 396: 23.12
+	Hs
		682162 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		AKT2_HUMAN (1-337): 6.85e-129: 396: 23.19
+	Hs
		931045 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		AKT3_HUMAN (10-351): 5.23e-128: 394: 24.29
+	Ce
		108325 PP2A_CAEEL (182-481): 6.63e-165: 470: 39.15		GCK1_CAEEL (12-448): 1.04e-118: 375: 31.77
+	Dm
		619909 PP2A_DROME (184-481): 8.45e-166: 472: 39.13		Q9VEN3_DROME (10-325): 3.79e-116: 368: 39.12
+	Hs
		131564 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		931026 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		STK26_HUMAN (1-396): 1.9e-116: 361: 33.84
+	Hs
		931059 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		STK24_HUMAN (9-295): 4.54e-116: 361: 42.36
+	Hs
		131559 PP4C_HUMAN (187-488): 7.07e-164: 467: 39.61		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Dm
		619891 PP2A_DROME (184-481): 8.45e-166: 472: 39.13		HIPPO_DROME (13-289): 5.89e-110: 353: 43.17
+	Mm
		915321 PP2AB_MOUSE (182-485): 6.26e-163: 465: 38.69		TNIK_MOUSE (11-296): 3.3e-64: 236: 42.57
+	Sc
		439624 PP2A1_YEAST (162-488): 6.84e-165: 472: 35.67		SPS1_YEAST (13-274): 1.01e-59: 213: 43.40
+	Sc
		439625 PP2A2_YEAST (164-482): 4.86e-162: 465: 35.00		SPS1_YEAST (13-274): 1.01e-59: 213: 43.40