Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.922

The method score is based on:

Property Details
Experiments 27238966, 21041660, 23354166, 26192437, 14532005
Identification Methods x-ray crystallography, affinity chromatography technology, protein kinase assay, pull down
Interaction Type association, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, POLO_box~POLO_box
Common GO terms GO:0000070 - mitotic sister chromatid segregation
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000132 - establishment of mitotic spindle orientation
GO:0000278 - mitotic cell cycle
and 67 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 603
Hs

1 603
+ Dr
+ Hs
+ Hs
+ Ce
+ Ce
+ Dm
+ Gm
+ At
+ At
+ At
+ At
+ At
+ Hs
+ Hs
+ Dm
+ Ce
+ Hs

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Last updated: 15 Jul 2024