HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	16339216
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051726 - regulation of cell cycle
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 1164
+	Hs
		1267564 PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		1073456 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		160683 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		861751 PLK1_HUMAN (1-603): 0: 617: 100.00		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		1268102 PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		254459 KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44		ROCK2_HUMAN (415-1038): 1.55e-24: 113: 11.27
+	Hs
		1071723 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		MRCKB_HUMAN (835-1162): 1.41e-15: 84.5: 6.67
+	Hs
		160561 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		129013 PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		160817 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		CACO1_HUMAN (620-1116): 8.08e-29: 126: 14.93
+	Hs
		160521 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		CENPE_HUMAN (620-984): 9.03e-10: 65.5: 20.36