Protein: NEDD4
E3 ubiquitin-protein ligase Nedd-4 (DNedd4) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4)

Gene: NEDD4
Organism: Drosophila melanogaster
Interactions: 31
UniProt ID: Q9VVI3

Gene Ontology (top 5):
GO:0002092 - positive regulation of receptor internalization
GO:0004842 - ubiquitin-protein transferase activity
GO:0005112 - Notch binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1267314

Q7KLE5
Amphiphysin

2

8

Small-scale

0.793

High

1445315

Q9NCC3
Sorting nexin

2

3

Small-scale

0.754

High

1487324

SUDX
E3 ubiquitin-protein ligase Su(dx)

2

15

High-throughput

0.737

High

615120

PTC
Protein patched

4

14

Small-scale

0.677

High

1172287

COMM
Protein commissureless 1

4

0

Small-scale

0.667

High

451922

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

13

Small-scale

0.618

High

1471584

Q9VDI1
LD46328p

1

5

Small-scale

0.618

High

1070707

Q0KHU0
Myosin 10A, isoform D

1

5

Small-scale

0.552

High

263208

TENM
Teneurin-m

1

13

High-throughput

0.484

High

1476257

Q9VHK4
Polychaetoid, isoform B

1

15

Small-scale

0.481

High

233563

SPY
Protein sprouty

1

3

High-throughput

0.479

High

263631

FLOT2
Flotillin-2

1

5

High-throughput

0.479

High

1344684

Q8SYU5
RE33762p

1

20

High-throughput

0.479

High

1475225

Q9VGU4
FI02822p

1

20

High-throughput

0.479

High

1476956

Q9VHZ7
LD29844p

1

20

High-throughput

0.479

High

1476974

Q9VI00
FI24305p1

1

20

High-throughput

0.479

High

1487321

Q9VVJ5
Nedd4 family interacting protein

1

17

Small-scale

0.479

High

263585

FLOT1
Flotillin-1

1

6

High-throughput

0.445

High

1478782

Q9VJW9
ADAM10 endopeptidase

1

2

High-throughput

0.445

High

1487323

Q9W4N8
LD30122p

1

1

High-throughput

0.445

High

1486657

FRL
Formin-like protein

1

3

High-throughput

0.437

High

1172096

DALY
Division abnormally delayed protein

1

0

High-throughput

0.426

High

1302744

Q8IGE8
RH36596p

1

1

High-throughput

0.417

High

1069723

Q0E924
Prohibitin

1

7

High-throughput

0.407

High

1472103

INO80
Chromatin-remodeling ATPase INO80

1

6

High-throughput

0.407

High

1474920

Q9VGN4
Sarcomere length short, isoform B

1

7

High-throughput

0.407

High

1486441

Q9VU19
WW domain binding protein 2, isoform E

1

17

High-throughput

0.407

High

1487322

Q9W0L7
ubiquitinyl hydrolase 1

1

9

High-throughput

0.407

High

1265640

Q7K3C2
LD38554p

2

0

High-throughput

0.305

High

1440750

Q9I7V5
LD43412p

1

0

High-throughput

0.249

Low

1467290

Q9VA35
CIN85 and CD2AP related, isoform A

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025