Protein: WBP2
WW domain-binding protein 2 (WBP-2)

Gene: WBP2
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q969T9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

862353

YAP1
Transcriptional coactivator YAP1

9

15

Small-scale

0.754

High

861709

NEDD4
E3 ubiquitin-protein ligase NEDD4

7

9

Small-scale

0.751

High

132214

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

7

9

Small-scale

0.744

High

1381237

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

5

9

Small-scale

0.708

High

1381227

ITCH
E3 ubiquitin-protein ligase Itchy homolog

4

9

Small-scale

0.697

High

1381242

HOME3
Homer protein homolog 3

3

1

Small-scale

0.672

High

347856

BAG3
BAG family molecular chaperone regulator 3

4

0

High-throughput

0.663

High

1381228

NED4L
E3 ubiquitin-protein ligase NEDD4-like

3

9

Small-scale

0.647

High

1381235

WWTR1
WW domain-containing transcription regulator protein 1

2

14

Small-scale

0.646

High

1381245

WWOX
WW domain-containing oxidoreductase

3

0

High-throughput

0.627

High

329474

EPN2
Epsin-2

3

0

Small-scale

0.626

High

127385

LEG8
Galectin-8

2

1

High-throughput

0.606

High

848343

MAGA4
Melanoma-associated antigen 4

2

1

High-throughput

0.584

High

1381174

UB2E3
Ubiquitin-conjugating enzyme E2 E3

2

0

High-throughput

0.580

High

1381232

SMAD5
Mothers against decapentaplegic homolog 5

2

0

High-throughput

0.580

High

1381233

TCPH
T-complex protein 1 subunit eta

2

0

High-throughput

0.580

High

896600

VASP
Vasodilator-stimulated phosphoprotein

2

3

Small-scale

0.571

High

396666

ESR1
Estrogen receptor

1

1

Small-scale

0.561

High

1381250

WWC3
Protein WWC3

1

12

Small-scale

0.561

High

1381229

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

2

3

Small-scale

0.553

High

1381236

TOLIP
Toll-interacting protein

2

0

Small-scale

0.552

High

1029897

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.541

High

446006

ENOA
Alpha-enolase

1

0

Small-scale

0.537

High

1050502

UBE3A
Ubiquitin-protein ligase E3A

1

10

Small-scale

0.527

High

1381231

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.513

High

773589

COPB2
Coatomer subunit beta'

1

1

Small-scale

0.501

High

921981

COPA
Coatomer subunit alpha

1

1

Small-scale

0.501

High

1381255

COPG1
Coatomer subunit gamma-1

1

1

Small-scale

0.501

High

1381256

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.493

High

508389

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.481

High

987149

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

Small-scale

0.481

High

987438

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

3

Small-scale

0.481

High

1256349

AN13D
Ankyrin repeat domain-containing protein 13D

1

1

Small-scale

0.481

High

1280391

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

9

Small-scale

0.481

High

1315825

AN13A
Ankyrin repeat domain-containing protein 13A

1

1

Small-scale

0.481

High

1381252

UBQL1
Ubiquilin-1

1

4

Small-scale

0.481

High

158279

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.480

High

436963

K1C18
Keratin, type I cytoskeletal 18

1

0

Small-scale

0.480

High

437295

K2C8
Keratin, type II cytoskeletal 8

1

0

Small-scale

0.480

High

658323

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.480

High

665479

EF1B
Elongation factor 1-beta

1

0

Small-scale

0.480

High

772041

K1C9
Keratin, type I cytoskeletal 9

1

0

Small-scale

0.480

High

873283

COPD
Coatomer subunit delta

1

0

Small-scale

0.480

High

921742

COPB
Coatomer subunit beta

1

0

Small-scale

0.480

High

980100

H4
Histone H4

1

0

Small-scale

0.480

High

1369339

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

Small-scale

0.480

High

1381241

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

Small-scale

0.480

High

363677

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

457603

TBB5
Tubulin beta chain

1

1

Small-scale

0.479

High

474877

VIME
Vimentin

1

2

Small-scale

0.479

High

570537

GFAP
Glial fibrillary acidic protein

1

2

Small-scale

0.479

High

767293

MERL
Merlin

1

2

High-throughput

0.479

High

934962

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

1254946

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1364195

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1372173

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.479

High

1381247

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

1381248

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

Small-scale

0.479

High

1381234

RAB34
Ras-related protein Rab-34

1

1

High-throughput

0.470

High

1169440

Q1RN33
Melanoma antigen A 4

1

1

High-throughput

0.470

High

339174

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

Small-scale

0.460

High

1315649

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.460

High

1381230

UIMC1
BRCA1-A complex subunit RAP80

1

0

Small-scale

0.460

High

1381239

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.460

High

1381251

MYO6
Unconventional myosin-VI

1

0

Small-scale

0.460

High

1381253

POLH
DNA polymerase eta

1

0

Small-scale

0.460

High

764949

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

1339643

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1381240

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

138516

BIN1
Myc box-dependent-interacting protein 1

1

5

High-throughput

0.457

High

328101

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

609771

LEG3
Galectin-3

1

2

High-throughput

0.445

High

952287

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.445

High

1110525

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

1381238

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

1381243

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

1256896

TM1L2
TOM1-like protein 2

1

2

Small-scale

0.439

High

106413

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

710412

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.437

High

1147818

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

1340605

SMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

1

0

High-throughput

0.426

High

1381249

RABX5
Rab5 GDP/GTP exchange factor

1

0

High-throughput

0.426

High

1364806

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

1249708

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.265

Low

724147

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

Small-scale

0.261

Low

1381244

CUED1
CUE domain-containing protein 1

1

0

Small-scale

0.251

Low

1381254

RHBD3
Rhomboid domain-containing protein 3

1

0

Small-scale

0.251

Low

178354

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

1381246

SEPT3
Neuronal-specific septin-3

1

0

High-throughput

0.238

Low

50649

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

944408

SYJ2B
Synaptojanin-2-binding protein

1

0

High-throughput

0.232

Low

1104040

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1381226

CC127
Coiled-coil domain-containing protein 127

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025