HitPredict

Interactor 1: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	20098747
Identification Methods	pull down, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~CC2-LZ
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006915 - apoptotic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1430 Hs			1 419
+	Hs
		862127 DAPK1_HUMAN (1-1430): 0: 1999: 100.00		MYO5B_HUMAN (64-394): 2.99e-18: 89.7: 16.95
+	Hs
		1039206 KCC2D_HUMAN (2-383): 1.06e-116: 377: 27.94		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Rn
		506776 KCC2A_RAT (1-383): 5.07e-120: 385: 29.17		MYO5A_RAT (38-342): 4.66e-27: 116: 14.01
+	Hs
		965180 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		200091 DAPK3_HUMAN (1-376): 1.82e-120: 385: 60.00		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		724782 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		725139 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		200129 DAPK3_HUMAN (1-376): 1.82e-120: 385: 60.00		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		1077872 MYLK_HUMAN (1-319): 4.96e-76: 281: 44.06		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Mm
		57810 KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91		D3YZ62_MOUSE (38-342): 2.25e-27: 117: 14.33
+	Mm
		57875 KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91		MYO5A_MOUSE (38-342): 1.6e-27: 117: 14.33
+	Hs
		724846 MYLK_HUMAN (1-319): 4.96e-76: 281: 44.06		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		883695 RIPK4_HUMAN (635-957): 2.79e-33: 141: 13.99		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		1330909 Q9H4D1_HUMAN (635-957): 5.06e-33: 140: 13.99		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Rn
		957077 KALRN_RAT (2-312): 1.07e-61: 236: 38.91		MRCKB_RAT (45-355): 2.08e-10: 65: 14.56
+	Rn
		222475 KALRN_RAT (2-312): 1.07e-61: 236: 38.91		MRCKA_RAT (77-391): 2.29e-09: 61.9: 16.30