HitPredict

Interactor 1: SUCA (P53597)
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
Gene: SUCLG1

Interactor 2: SUCB2 (Q96I99)
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)
Gene: SUCLG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	28514442, 33961781, 37071682, 32627745
Identification Methods	affinity chromatography technology, cross-linking study, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	ATP-grasp_2~CoA_binding, CoA_binding~Ligase_CoA, ATP-grasp_2~Ligase_CoA, Ligase_CoA~Ligase_CoA
Common GO terms	GO:0004776 - succinate-CoA ligase (GDP-forming) activity GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006099 - tricarboxylic acid cycle GO:0045244 - succinate-CoA ligase complex (GDP-forming) and 1 others more... GO:1901289 - succinyl-CoA catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 432
+	Ss
		186315 SUCA_PIG (1-346): 7.36e-148: 422: 94.51		SUCB2_PIG (2-432): 0: 627: 94.66
+	Hs
		863028 SUCA_HUMAN (1-346): 4.06e-146: 417: 100.00		SUCB1_HUMAN (36-430): 0: 566: 53.17
+	Sc
		861388 SUCA_YEAST (43-344): 5.35e-124: 360: 59.48		SUCB_YEAST (23-429): 0: 533: 46.34
+	Ec
		462865 SUCD_ECOLI (49-341): 4.73e-130: 374: 65.53		SUCC_ECOLI (38-432): 9.47e-167: 475: 43.80
+	Cj
		1010424 Q0PAY2_CAMJE (49-341): 1.23e-118: 345: 51.20		SUCC_CAMJE (38-431): 7.18e-161: 460: 42.03
+	Hs
		862360 ACLY_HUMAN (3-344): 6.67e-124: 383: 24.86		ACLY_HUMAN (39-412): 7.62e-131: 405: 23.32