HitPredict

Interactor 1: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31723608
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CC2-LZ~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 409 Hs			1 577
+	Rn
		1100599 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		MYH4_RAT (226-567): 2.42e-12: 72.2: 11.82
+	Hs
		1287428 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		872206 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		1355429 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		502884 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64
+	Hs
		475130 UBB_HUMAN (1-79): 1.99e-32: 123: 30.38		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1078927 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Mm
		291775 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		NEMO_MOUSE (204-576): 2.74e-40: 153: 25.33
+	Hs
		475262 UBB_HUMAN (1-79): 1.99e-32: 123: 30.38		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		924113 RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		725058 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		1061266 UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		924299 RL40_HUMAN (1-91): 3.57e-33: 122: 28.57		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Mm
		476828 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		MYH10_MOUSE (233-561): 5.58e-13: 74.5: 11.18
+	Hs
		475174 UBB_HUMAN (1-79): 1.99e-32: 123: 30.38		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		924399 RL40_HUMAN (1-91): 3.57e-33: 122: 28.57		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Mm
		477062 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09
+	Mm
		476930 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		MYH9_MOUSE (266-576): 6.92e-10: 64.5: 13.51
+	Hs
		923995 RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		148651 RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59