HitPredict

Interactor 1: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Interactor 2: FBXW4 (P57775)
F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)
Gene: FBXW4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 33961781, 23658844
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 541 Hs			1 412
+	Hs
		881848 TCPG_HUMAN (14-540): 0: 574: 33.15		FBXW4_HUMAN (21-412): 6.14e-83: 261: 98.22
+	Hs
		945590 TCPH_HUMAN (12-539): 0: 572: 29.64		FBXW4_HUMAN (21-412): 6.14e-83: 261: 98.22
+	Hs
		876081 TCPE_HUMAN (1-541): 0: 637: 100.00		POC1B_HUMAN (238-411): 9.78e-36: 138: 10.92
+	Hs
		882014 TCPG_HUMAN (14-540): 0: 574: 33.15		WDR5B_HUMAN (33-319): 6.84e-61: 201: 12.80
+	Hs
		1291941 TCPH_HUMAN (12-539): 0: 572: 29.64		WDR5B_HUMAN (33-319): 6.84e-61: 201: 12.80
+	Hs
		876070 TCPE_HUMAN (1-541): 0: 637: 100.00		POC1A_HUMAN (43-189): 1.38e-27: 114: 9.27
+	Hs
		882075 TCPG_HUMAN (14-540): 0: 574: 33.15		FBXW7_HUMAN (24-276): 2.08e-43: 163: 15.27
+	Hs
		876045 TCPE_HUMAN (1-541): 0: 637: 100.00		WDR86_HUMAN (153-399): 2.13e-22: 99.5: 17.74
+	Hs
		875898 TCPE_HUMAN (1-541): 0: 637: 100.00		WDR5_HUMAN (22-189): 2.63e-20: 92.9: 10.56
+	Hs
		876199 TCPE_HUMAN (1-541): 0: 637: 100.00		NLE1_HUMAN (328-411): 3.97e-17: 84.9: 11.91
+	Hs
		845257 TCPG_HUMAN (14-540): 0: 574: 33.15		LIS1_HUMAN (36-230): 3.86e-36: 138: 13.18
+	Hs
		882051 TCPG_HUMAN (14-540): 0: 574: 33.15		POC1B_HUMAN (238-411): 9.78e-36: 138: 10.92
+	Hs
		876112 TCPE_HUMAN (1-541): 0: 637: 100.00		SNR40_HUMAN (322-411): 1.37e-13: 73.3: 14.29
+	Hs
		876230 TCPE_HUMAN (1-541): 0: 637: 100.00		FBW1A_HUMAN (39-151): 1.15e-09: 62.1: 10.83
+	Hs
		882038 TCPG_HUMAN (14-540): 0: 574: 33.15		POC1A_HUMAN (43-189): 1.38e-27: 114: 9.27
+	Hs
		882009 TCPG_HUMAN (14-540): 0: 574: 33.15		WDR86_HUMAN (153-399): 2.13e-22: 99.5: 17.74
+	Hs
		1287302 TCPH_HUMAN (12-539): 0: 572: 29.64		WDR86_HUMAN (153-399): 2.13e-22: 99.5: 17.74
+	Hs
		881861 TCPG_HUMAN (14-540): 0: 574: 33.15		WDR5_HUMAN (22-189): 2.63e-20: 92.9: 10.56
+	Hs
		965190 TCPH_HUMAN (12-539): 0: 572: 29.64		WDR5_HUMAN (22-189): 2.63e-20: 92.9: 10.56
+	Hs
		882222 TCPG_HUMAN (14-540): 0: 574: 33.15		FBW1A_HUMAN (39-151): 1.15e-09: 62.1: 10.83