Protein: FBXW4
F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)

Gene: FBXW4
Organism: Homo sapiens
Interactions: 58
UniProt ID: P57775

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016055 - Wnt signaling pathway
GO:0019005 - SCF ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

945567

SKP1
S-phase kinase-associated protein 1

6

20

Small-scale

0.943

High

945575

CUL1
Cullin-1

6

20

Small-scale

0.935

High

610590

TCPA
T-complex protein 1 subunit alpha

4

20

Small-scale

0.895

High

875888

TCPE
T-complex protein 1 subunit epsilon

4

20

Small-scale

0.895

High

881848

TCPG
T-complex protein 1 subunit gamma

4

20

Small-scale

0.895

High

898970

TCPQ
T-complex protein 1 subunit theta

4

20

Small-scale

0.895

High

899314

TCPD
T-complex protein 1 subunit delta

4

20

Small-scale

0.895

High

945568

TCPB
T-complex protein 1 subunit beta

4

20

Small-scale

0.895

High

945590

TCPH
T-complex protein 1 subunit eta

4

20

Small-scale

0.895

High

821277

TCPZ
T-complex protein 1 subunit zeta

3

20

High-throughput

0.861

High

945574

PHLP
Phosducin-like protein

3

9

High-throughput

0.861

High

945584

TCPW
T-complex protein 1 subunit zeta-2

3

20

High-throughput

0.861

High

945595

PDCL3
Phosducin-like protein 3

3

9

High-throughput

0.861

High

155743

TXND9
Thioredoxin domain-containing protein 9

3

9

High-throughput

0.667

High

241235

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.665

High

945580

ANR39
Ankyrin repeat domain-containing protein 39

1

17

High-throughput

0.618

High

608518

DDX5
Probable ATP-dependent RNA helicase DDX5

1

15

Small-scale

0.618

High

945571

DHX9
ATP-dependent RNA helicase A

1

17

Small-scale

0.618

High

945578

SKI2
Superkiller complex protein 2

1

20

Small-scale

0.618

High

945588

PFD5
Prefoldin subunit 5

2

6

High-throughput

0.611

High

945597

PDRG1
p53 and DNA damage-regulated protein 1

3

1

High-throughput

0.609

High

945583

CSN6
COP9 signalosome complex subunit 6

2

4

Small-scale

0.571

High

945576

CUL4A
Cullin-4A

1

20

High-throughput

0.553

High

945579

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.541

High

945601

PFD2
Prefoldin subunit 2

1

4

High-throughput

0.536

High

945591

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.518

High

945593

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

945604

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

14

High-throughput

0.494

High

945582

SPT6H
Transcription elongation factor SPT6

1

6

High-throughput

0.489

High

681137

PSA2
Proteasome subunit alpha type-2

1

6

Small-scale

0.479

High

717745

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

9

Small-scale

0.479

High

718092

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

9

Small-scale

0.479

High

945566

CSN2
COP9 signalosome complex subunit 2

1

7

Small-scale

0.479

High

945570

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

945572

CSN1
COP9 signalosome complex subunit 1

1

6

Small-scale

0.479

High

945573

REST
RE1-silencing transcription factor

1

4

Small-scale

0.479

High

945577

DCTN1
Dynactin subunit 1

1

15

Small-scale

0.479

High

945585

NU205
Nuclear pore complex protein Nup205

1

1

Small-scale

0.479

High

945586

CSN5
COP9 signalosome complex subunit 5

1

6

Small-scale

0.479

High

945592

CSN4
COP9 signalosome complex subunit 4

1

2

Small-scale

0.479

High

945594

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

945596

CSN7B
COP9 signalosome complex subunit 7b

1

5

Small-scale

0.479

High

945598

NLK
Serine/threonine-protein kinase NLK

1

9

Small-scale

0.479

High

945599

CSN7A
COP9 signalosome complex subunit 7a

1

5

Small-scale

0.479

High

945600

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

945602

CSN3
COP9 signalosome complex subunit 3

1

7

Small-scale

0.479

High

945603

RUVB1
RuvB-like 1

1

5

Small-scale

0.479

High

945589

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.458

High

369644

A2MG
Alpha-2-macroglobulin

1

2

High-throughput

0.439

High

214755

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

13

Small-scale

0.437

High

261781

PFD1
Prefoldin subunit 1

1

5

Small-scale

0.437

High

298693

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

2

Small-scale

0.437

High

755675

MCM4
DNA replication licensing factor MCM4

1

8

Small-scale

0.437

High

923655

RCAN1
Calcipressin-1

1

2

Small-scale

0.437

High

945569

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

9

Small-scale

0.437

High

945587

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

945581

SLX4I
Protein SLX4IP

1

0

High-throughput

0.279

Low

407843

SEMG1
Semenogelin-1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025