HitPredict

Interactor 1: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Interactor 2: NLRP1 (Q9C000)
NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]
Gene: NLRP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 11113115, 11076957
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0008233 - peptidase activity
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 416
Hs

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Last updated: 15 Jul 2024