Protein: PKHG3
Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)

Gene: PKHG3, PLEKHG3
Organism: Homo sapiens
Interactions: 119
UniProt ID: A1L390

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0030334 - regulation of cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

51114

ANLN
Anillin

3

4

High-throughput

0.847

High

51059

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

51066

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

51128

AKT3
RAC-gamma serine/threonine-protein kinase

1

8

High-throughput

0.691

High

51061

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

51073

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

51046

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.624

High

51013

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

51027

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

51037

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

51058

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

51060

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

51067

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

51069

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

51112

ECT2
Protein ECT2

1

16

High-throughput

0.618

High

51054

CAZA2
F-actin-capping protein subunit alpha-2

2

3

High-throughput

0.611

High

51048

LSP1
Lymphocyte-specific protein 1

2

0

High-throughput

0.602

High

51087

PKHA7
Pleckstrin homology domain-containing family A member 7

1

11

High-throughput

0.575

High

51024

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

51042

1433T
14-3-3 protein theta

2

20

High-throughput

0.571

High

51064

RS29
Small ribosomal subunit protein uS14

2

4

High-throughput

0.571

High

51085

SYDE2
Rho GTPase-activating protein SYDE2

2

6

High-throughput

0.571

High

51102

AURKB
Aurora kinase B

2

7

High-throughput

0.571

High

51117

TMOD2
Tropomodulin-2

2

13

High-throughput

0.571

High

51127

CHM2B
Charged multivesicular body protein 2b

2

2

High-throughput

0.571

High

51039

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

51111

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

51119

ZMYM2
Zinc finger MYM-type protein 2

2

0

High-throughput

0.547

High

51012

MYO1C
Unconventional myosin-Ic

1

14

High-throughput

0.536

High

51025

S100B
Protein S100-B

1

7

High-throughput

0.536

High

51040

FLNA
Filamin-A

1

14

High-throughput

0.536

High

51050

MYH9
Myosin-9

1

7

High-throughput

0.536

High

51053

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

7

High-throughput

0.536

High

51062

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

10

High-throughput

0.536

High

51065

ACTA
Actin, aortic smooth muscle

1

6

High-throughput

0.536

High

51074

AHNK
Neuroblast differentiation-associated protein AHNAK

1

6

High-throughput

0.536

High

51077

SRC8
Src substrate cortactin

1

14

High-throughput

0.536

High

51082

DREB
Drebrin

1

4

High-throughput

0.536

High

51103

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.536

High

51120

LIMA1
LIM domain and actin-binding protein 1

1

12

High-throughput

0.536

High

51122

KLH21
Kelch-like protein 21

1

8

High-throughput

0.536

High

51123

NXT1
NTF2-related export protein 1

1

2

High-throughput

0.536

High

51021

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.533

High

51016

KDM1A
Lysine-specific histone demethylase 1A

2

1

High-throughput

0.521

High

51088

POTEE
POTE ankyrin domain family member E

2

16

High-throughput

0.521

High

51020

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.513

High

51093

ABRA
Actin-binding Rho-activating protein

1

0

High-throughput

0.513

High

51113

PNRC2
Proline-rich nuclear receptor coactivator 2

1

0

High-throughput

0.513

High

51115

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.513

High

51124

PLAT4
Phospholipase A and acyltransferase 4

1

0

High-throughput

0.513

High

51019

MYO1D
Unconventional myosin-Id

1

15

High-throughput

0.489

High

51029

POTEI
POTE ankyrin domain family member I

1

16

High-throughput

0.489

High

51041

S100P
Protein S100-P

1

7

High-throughput

0.489

High

51044

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

51083

ACTBL
Beta-actin-like protein 2

1

14

High-throughput

0.489

High

51094

KC1AL
Casein kinase I isoform alpha-like

1

6

High-throughput

0.489

High

51099

MY18A
Unconventional myosin-XVIIIa

1

12

High-throughput

0.489

High

51022

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

12

High-throughput

0.479

High

51026

GELS
Gelsolin

1

6

High-throughput

0.479

High

51033

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

51047

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

51055

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

51057

ACTB
Actin, cytoplasmic 1

1

15

High-throughput

0.479

High

51063

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.479

High

51068

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

51072

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

51078

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

51079

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

51080

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

1

High-throughput

0.479

High

51086

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.479

High

51109

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

51118

ANFY1
Rabankyrin-5

1

7

High-throughput

0.479

High

51121

XPO7
Exportin-7

1

8

High-throughput

0.479

High

51084

SPIN3
Spindlin-3

1

0

High-throughput

0.458

High

51096

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.458

High

51110

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

51014

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

3

High-throughput

0.445

High

51023

TNNC2
Troponin C, skeletal muscle

1

2

High-throughput

0.445

High

51034

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.445

High

51035

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

51038

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

9

High-throughput

0.445

High

51043

TMOD1
Tropomodulin-1

1

11

High-throughput

0.445

High

51045

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

8

High-throughput

0.445

High

51051

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

10

High-throughput

0.445

High

51052

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

4

High-throughput

0.445

High

51070

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.445

High

51081

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

High-throughput

0.445

High

51108

TOLIP
Toll-interacting protein

1

1

High-throughput

0.445

High

51126

COR2B
Coronin-2B

1

16

High-throughput

0.445

High

51129

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

1

High-throughput

0.445

High

51028

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

11

High-throughput

0.437

High

51056

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.437

High

51071

LMNB2
Lamin-B2

1

9

High-throughput

0.437

High

51075

CIRBP
Cold-inducible RNA-binding protein

1

11

High-throughput

0.437

High

51097

TM263
Transmembrane protein 263

1

4

High-throughput

0.437

High

51100

ESR2
Estrogen receptor beta

1

19

High-throughput

0.437

High

51130

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.437

High

51036

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.426

High

51030

ST3L3
STAG3-like protein 3

1

1

High-throughput

0.407

High

51032

CALM3
Calmodulin-3

1

1

High-throughput

0.407

High

51089

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

51091

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

3

High-throughput

0.407

High

51095

CCD89
Coiled-coil domain-containing protein 89

1

4

High-throughput

0.407

High

51031

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

51049

IL13
Interleukin-13

1

0

High-throughput

0.279

Low

51076

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

51092

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.279

Low

51098

JPH3
Junctophilin-3

1

0

High-throughput

0.279

Low

51101

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

51104

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

51105

S39A3
Zinc transporter ZIP3

1

0

High-throughput

0.279

Low

51107

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.279

Low

51125

MUCEN
Endomucin

1

0

High-throughput

0.279

Low

51015

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.249

Low

51018

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.249

Low

51090

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

51017

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.232

Low

51106

NICN1
Nicolin-1

1

0

High-throughput

0.232

Low

51116

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025