HitPredict

Interactor 1: FOXA1 (P55317)
Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)
Gene: FOXA1

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 472 Hs			1 770
+	Hs
		877704 FOXA1_HUMAN (1-472): 5.65e-93: 291: 100.00		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		980669 FOXA2_HUMAN (1-472): 1.2e-66: 222: 42.62		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		877602 FOXG1_HUMAN (17-470): 1.3e-61: 210: 22.32		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980596 FOXL1_HUMAN (143-337): 1.76e-55: 190: 42.86		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Rn
		88552 FOXG1_RAT (17-470): 4.59e-64: 216: 23.18		D3ZCM7_RAT (1-770): 0: 566: 96.24
+	Mm
		1141982 FOXG1_MOUSE (17-470): 2.18e-62: 212: 23.56		TLE1_MOUSE (1-770): 0: 563: 97.15
+	Hs
		877990 FOXA3_HUMAN (1-414): 4.01e-48: 170: 38.65		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980931 FOXL1_HUMAN (143-337): 1.76e-55: 190: 42.86		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		980742 FOXL1_HUMAN (143-337): 1.76e-55: 190: 42.86		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		980740 FOXC1_HUMAN (130-457): 7.84e-49: 177: 31.42		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		993408 FOXL1_HUMAN (143-337): 1.76e-55: 190: 42.86		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Ce
		137682 FKH02_CAEEL (112-324): 1.26e-51: 177: 27.06		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Ce
		137678 UN130_CAEEL (51-373): 9.43e-50: 174: 25.00		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Hs
		877671 FOXA1_HUMAN (1-472): 5.65e-93: 291: 100.00		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		877636 FOXG1_HUMAN (17-470): 1.3e-61: 210: 22.32		TLE6_HUMAN (463-770): 1.51e-47: 179: 33.65
+	Hs
		952865 FOXK1_HUMAN (107-373): 2.04e-54: 195: 27.24		TBL1R_HUMAN (558-769): 4.54e-47: 177: 15.65
+	Hs
		245597 FOXL1_HUMAN (143-337): 1.76e-55: 190: 42.86		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		1021159 FOXC1_HUMAN (130-457): 7.84e-49: 177: 31.42		TBL1R_HUMAN (558-769): 4.54e-47: 177: 15.65
+	Dm
		970548 FD3_DROME (92-273): 2.21e-53: 187: 42.86		Q9VVI0_DROME (548-761): 3.09e-14: 78.2: 26.58
+	Hs
		1021146 FOXC1_HUMAN (130-457): 7.84e-49: 177: 31.42		SNR40_HUMAN (507-675): 1.08e-09: 62.8: 28.18