HitPredict

Interactor 1: JAM2 (P57087)
Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)
Gene: JAM2

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12953056
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction GO:0035633 - maintenance of blood-brain barrier GO:0070160 - tight junction GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 1748
+	Hs
		990924 JAM3_HUMAN (1-298): 5.16e-57: 187: 34.08		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		990962 JAM1_HUMAN (1-298): 6.57e-56: 184: 34.11		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		940406 CXAR_HUMAN (10-286): 7.65e-45: 157: 20.74		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		159294 JAM1_HUMAN (1-298): 6.57e-56: 184: 34.11		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Rn
		73320 JAM3_RAT (28-298): 5.47e-55: 182: 34.52		PALS1_RAT (299-806): 5.18e-84: 292: 16.43
+	Hs
		159144 FGFR1_HUMAN (40-283): 4.41e-43: 159: 19.46		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		508052 FGFR1_HUMAN (40-283): 4.41e-43: 159: 19.46		MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96
+	Hs
		940450 CXAR_HUMAN (10-286): 7.65e-45: 157: 20.74		MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96
+	Hs
		609417 FGFR3_HUMAN (32-285): 3.81e-41: 153: 18.41		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Hs
		507970 FGFR1_HUMAN (40-283): 4.41e-43: 159: 19.46		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		940410 CXAR_HUMAN (10-286): 7.65e-45: 157: 20.74		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Mm
		292319 JAM1_MOUSE (4-298): 7.36e-53: 176: 34.22		MPDZ_MOUSE (418-540): 2.31e-13: 78: 25.19
+	Hs
		508118 FGFR1_HUMAN (40-283): 4.41e-43: 159: 19.46		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		940411 CXAR_HUMAN (10-286): 7.65e-45: 157: 20.74		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		280018 FGFR3_HUMAN (32-285): 3.81e-41: 153: 18.41		MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61
+	Mm
		936319 DCC_MOUSE (4-297): 3.12e-30: 122: 16.15		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Hs
		601553 FGFR2_HUMAN (40-284): 1.29e-38: 146: 18.82		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Mm
		530208 NCAM1_MOUSE (27-240): 9.56e-28: 114: 21.40		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Hs
		508096 FGFR1_HUMAN (40-283): 4.41e-43: 159: 19.46		UNC5B_HUMAN (1634-1718): 3.49e-11: 70.5: 44.71
+	Hs
		940591 CXAR_HUMAN (10-286): 7.65e-45: 157: 20.74		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98