HitPredict

Interactor 1: H2B1D (P58876)
Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b)
Gene: H2BC5

Interactor 2: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36373674
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 1101
+	Hs
		1129824 H2B2F_HUMAN (1-126): 3.9e-54: 167: 97.62		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221679 H2B1M_HUMAN (1-126): 4.45e-54: 167: 96.83		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221621 H2B1H_HUMAN (1-126): 8.88e-54: 166: 98.41		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		241580 H2B1K_HUMAN (1-126): 2.11e-53: 165: 98.41		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221678 H2B1N_HUMAN (1-126): 3.49e-53: 164: 99.21		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221680 H2B1L_HUMAN (1-126): 3.72e-52: 162: 97.62		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221624 H2B1A_HUMAN (1-126): 5.53e-46: 146: 85.04		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1274480 H2B1H_HUMAN (1-126): 8.88e-54: 166: 98.41		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		420896 H2B1J_HUMAN (1-126): 1.25e-53: 166: 97.62		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		241662 H2B1K_HUMAN (1-126): 2.11e-53: 165: 98.41		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		918774 H2B1C_HUMAN (1-126): 1.71e-53: 165: 99.21		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Sc
		355931 H2B2_YEAST (3-125): 5.98e-40: 131: 70.73		SMC3_YEAST (51-1055): 7.78e-71: 260: 13.66
+	Hs
		311555 H2B2E_HUMAN (1-126): 9.91e-54: 166: 98.41		SMC2_HUMAN (51-1055): 9.8e-55: 210: 11.41
+	Sc
		355483 H2B1_YEAST (3-125): 4.79e-36: 121: 70.73		SMC2_YEAST (51-1064): 1.41e-54: 209: 12.04
+	Hs
		725214 H2B1H_HUMAN (1-126): 8.88e-54: 166: 98.41		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60
+	Hs
		241464 H2B1K_HUMAN (1-126): 2.11e-53: 165: 98.41		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60
+	Hs
		725122 H2B1D_HUMAN (1-126): 2.74e-53: 165: 100.00		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60
+	Hs
		725133 H2B1C_HUMAN (1-126): 1.71e-53: 165: 99.21		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60
+	Hs
		725231 H2B1L_HUMAN (1-126): 3.72e-52: 162: 97.62		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60
+	Hs
		1274476 H2B1H_HUMAN (1-126): 8.88e-54: 166: 98.41		MYH2_HUMAN (112-552): 2.43e-12: 73.9: 8.44