HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: MCM6 (Q14566)
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene: MCM6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 26496610, 27173435, 17296731, 12694531, 12614612, 12207017, 39358380, 31839598, 25416956, 16189514, 25963833, 30100344, 10567526, 33961781, 35235311, 37071682, 26167883, 20211142
Identification Methods affinity chromatography technology, pull down, two hybrid, cross-linking study, biochemical, anti tag coimmunoprecipitation, validated two hybrid, two hybrid array, tandem affinity purification, two hybrid prey pooling approach and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM6_C, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM6_C~MCM_lid, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003678 - DNA helicase activity
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
and 9 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 904
Hs

1 821
+ Xl
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Xl
+ Xl
+ Xl
+ At
+ Ce
+ Dm
+ Dm
+ Sp
+ Dm
+ Sp
+ Xl
+ Sp

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Last updated: 11Aug2025