HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: TNPO3 (Q9Y5L0)
Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
Gene: TNPO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 923
+	Hs
		889534 CLK1_HUMAN (1-484): 2.4e-143: 422: 53.31		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		889846 CLK3_HUMAN (1-499): 4.5e-133: 395: 59.32		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		172404 CDK1_HUMAN (160-483): 1.01e-113: 339: 24.10		XPO1_HUMAN (3-920): 6.79e-151: 475: 12.37
+	Xl
		772461 CDK1A_XENLA (160-484): 2.71e-114: 341: 24.63		Q6NS03_XENLA (3-918): 4.59e-148: 467: 12.80
+	Hs
		172793 DYR1A_HUMAN (108-485): 8.54e-105: 331: 28.50		XPO1_HUMAN (3-920): 6.79e-151: 475: 12.37
+	Sp
		569559 HOG1_SCHPO (158-498): 1.02e-111: 336: 23.12		XPO1_SCHPO (3-920): 1.67e-123: 402: 13.26
+	Hs
		334686 CDK2_HUMAN (160-488): 2.04e-132: 387: 24.70		IPO7_HUMAN (13-813): 8.67e-101: 340: 11.63
+	Hs
		889736 CLK3_HUMAN (1-499): 4.5e-133: 395: 59.32		IMB1_HUMAN (38-691): 1.58e-09: 64.1: 9.56
+	Hs
		667855 CDK2_HUMAN (160-488): 2.04e-132: 387: 24.70		IMB1_HUMAN (38-691): 1.58e-09: 64.1: 9.56
+	Hs
		1134444 DYR1B_HUMAN (108-488): 3.01e-110: 341: 29.03		IMB1_HUMAN (38-691): 1.58e-09: 64.1: 9.56
+	Hs
		1115662 DYR1A_HUMAN (108-485): 8.54e-105: 331: 28.50		IMB1_HUMAN (38-691): 1.58e-09: 64.1: 9.56