Protein: DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)

Gene: DYR1B, DYRK1B
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q9Y463

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

605862

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

2

19

High-throughput

0.811

High

629180

CCNA2
Cyclin-A2

2

20

High-throughput

0.811

High

1017517

FOXK1
Forkhead box protein K1

2

12

High-throughput

0.811

High

1365826

ZN516
Zinc finger protein 516

2

3

High-throughput

0.811

High

462077

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

468948

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

858738

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

20

Small-scale

0.789

High

1158210

MK14
Mitogen-activated protein kinase 14

2

19

Small-scale

0.768

High

964781

DCAF7
DDB1- and CUL4-associated factor 7

11

20

Small-scale

0.759

High

531183

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

10

High-throughput

0.726

High

1452557

FA53C
Protein FAM53C

5

2

High-throughput

0.722

High

703754

MK01
Mitogen-activated protein kinase 1

1

17

Small-scale

0.710

High

1096526

PAK1
Serine/threonine-protein kinase PAK 1

1

20

High-throughput

0.698

High

277200

ZN217
Zinc finger protein 217

1

3

High-throughput

0.691

High

668085

CDK2
Cyclin-dependent kinase 2

1

17

High-throughput

0.691

High

701945

ABCD3
ATP-binding cassette sub-family D member 3

1

2

High-throughput

0.691

High

920393

PLK1
Serine/threonine-protein kinase PLK1

1

20

High-throughput

0.691

High

1098870

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

19

Small-scale

0.691

High

1106147

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.691

High

1158008

DDB1
DNA damage-binding protein 1

1

3

High-throughput

0.691

High

1214085

KIF24
Kinesin-like protein KIF24

1

13

High-throughput

0.691

High

1144230

TEBP
Prostaglandin E synthase 3

3

7

High-throughput

0.675

High

1335899

RN169
E3 ubiquitin-protein ligase RNF169

3

4

Small-scale

0.667

High

1411395

LZTS2
Leucine zipper putative tumor suppressor 2

5

20

High-throughput

0.666

High

442838

RB
Retinoblastoma-associated protein

2

14

High-throughput

0.658

High

705000

RBL1
Retinoblastoma-like protein 1

2

14

High-throughput

0.658

High

1086523

TROAP
Tastin

4

1

High-throughput

0.649

High

1491326

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

19

Small-scale

0.647

High

1240813

F117B
Protein FAM117B

4

5

High-throughput

0.643

High

132778

BMAL1
Basic helix-loop-helix ARNT-like protein 1

2

4

High-throughput

0.628

High

941618

CTBP2
C-terminal-binding protein 2

2

11

High-throughput

0.628

High

991784

DYL1
Dynein light chain 1, cytoplasmic

2

4

High-throughput

0.628

High

1065687

RBL2
Retinoblastoma-like protein 2

2

14

High-throughput

0.628

High

1067873

EP300
Histone acetyltransferase p300

2

17

High-throughput

0.628

High

1214839

ATD3B
ATPase family AAA domain-containing protein 3B

2

11

High-throughput

0.628

High

1363925

LPIN2
Phosphatidate phosphatase LPIN2

2

6

High-throughput

0.628

High

1366105

K0232
Uncharacterized protein KIAA0232

2

1

High-throughput

0.628

High

1368537

CBP
CREB-binding protein

2

17

High-throughput

0.628

High

1396763

EP400
E1A-binding protein p400

2

5

High-throughput

0.628

High

1460993

AKA11
A-kinase anchor protein 11

2

1

High-throughput

0.628

High

1491328

ARIP4
Helicase ARIP4

2

10

High-throughput

0.628

High

635226

HNF1A
Hepatocyte nuclear factor 1-alpha

2

1

Small-scale

0.619

High

243380

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.618

High

1153383

MK11
Mitogen-activated protein kinase 11

1

19

Small-scale

0.618

High

1432282

HIPK2
Homeodomain-interacting protein kinase 2

1

20

Small-scale

0.618

High

192402

GSC2
Homeobox protein goosecoid-2

2

6

High-throughput

0.606

High

1402357

RANB9
Ran-binding protein 9

1

12

Small-scale

0.594

High

244906

LZTS3
Leucine zipper putative tumor suppressor 3

2

20

High-throughput

0.574

High

1254208

PPR3F
Protein phosphatase 1 regulatory subunit 3F

2

1

High-throughput

0.574

High

1258767

CEFIP
Cardiac-enriched FHL2-interacting protein

2

1

High-throughput

0.574

High

1291390

GLCI1
Glucocorticoid-induced transcript 1 protein

2

5

High-throughput

0.574

High

1309189

MISP
Mitotic interactor and substrate of PLK1

2

2

High-throughput

0.574

High

1420600

F117A
Protein FAM117A

2

5

High-throughput

0.574

High

1454573

SI1L2
Signal-induced proliferation-associated 1-like protein 2

2

11

High-throughput

0.574

High

1036562

ID2
DNA-binding protein inhibitor ID-2

1

6

Small-scale

0.561

High

961658

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

Small-scale

0.552

High

1430249

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

1

Small-scale

0.552

High

1399951

FACOS
FANCD2 opposite strand protein

2

1

High-throughput

0.549

High

244621

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

14

High-throughput

0.536

High

279003

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.536

High

555442

SKI
Ski oncogene

1

4

High-throughput

0.536

High

907637

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

14

High-throughput

0.536

High

1017391

SKOR1
SKI family transcriptional corepressor 1

1

4

High-throughput

0.536

High

1103471

CTBP1
C-terminal-binding protein 1

1

11

High-throughput

0.536

High

1178126

RFX7
DNA-binding protein RFX7

1

3

High-throughput

0.536

High

1226013

ICE2
Little elongation complex subunit 2

1

1

High-throughput

0.536

High

1435971

KAT8
Histone acetyltransferase KAT8

1

4

High-throughput

0.536

High

1452928

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.536

High

1461618

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.536

High

1490696

ICE1
Little elongation complex subunit 1

1

2

High-throughput

0.536

High

1491327

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.536

High

1353110

ARH40
Rho guanine nucleotide exchange factor 40

2

4

High-throughput

0.521

High

1328611

MS3L1
MSL complex subunit 3

1

0

High-throughput

0.513

High

1462751

HDAC5
Histone deacetylase 5

1

10

Small-scale

0.501

High

208765

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

12

High-throughput

0.489

High

1260721

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

13

High-throughput

0.489

High

1331384

ENAH
Protein enabled homolog

1

13

High-throughput

0.489

High

1445759

WDR6
tRNA

1

20

High-throughput

0.489

High

730984

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

842894

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

15

High-throughput

0.479

High

972170

1433E
14-3-3 protein epsilon

1

16

High-throughput

0.479

High

1134444

IMB1
Importin subunit beta-1

1

4

High-throughput

0.479

High

1143879

TCAL1
Transcription elongation factor A protein-like 1

1

1

High-throughput

0.479

High

1357618

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1396438

EGLN2
Prolyl hydroxylase EGLN2

1

6

Small-scale

0.479

High

1400323

PKH4B
Pleckstrin homology domain-containing family G member 4B

1

6

High-throughput

0.479

High

1401467

CIC
Protein capicua homolog

1

19

High-throughput

0.479

High

1462284

CHIP
E3 ubiquitin-protein ligase CHIP

1

11

High-throughput

0.479

High

68025

P121C
Nuclear envelope pore membrane protein POM 121C

1

19

High-throughput

0.445

High

756423

MCM7
DNA replication licensing factor MCM7

1

7

Small-scale

0.445

High

1330269

ARF
Tumor suppressor ARF

1

1

High-throughput

0.445

High

76163

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

12

High-throughput

0.437

High

1178481

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1253685

PKHG7
Pleckstrin homology domain-containing family G member 7

1

7

High-throughput

0.437

High

1227765

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.407

High

1400205

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

8

High-throughput

0.407

High

228876

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025