HitPredict

Interactor 1: MYL6 (P60660)
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)
Gene: MYL6

Interactor 2: MY18A (Q92614)
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
Gene: MYO18A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane GO:0016460 - myosin II complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 151 Hs			1 2054
+	Hs
		521686 MYL4_HUMAN (3-151): 7.24e-58: 180: 77.48		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		441675 MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		538690 MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		484173 CALM3_HUMAN (5-77): 1.13e-11: 60.6: 28.77		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Dm
		870146 MLC2_DROME (1-151): 6.78e-55: 171: 53.64		MYO7A_DROME (347-1359): 0: 824: 21.39
+	Gg
		361265 MYL6_CHICK (1-151): 1.02e-51: 162: 89.40		MYH11_CHICK (1206-2044): 7.34e-58: 224: 16.17
+	Hs
		441665 MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Dm
		870145 MLC2_DROME (1-151): 6.78e-55: 171: 53.64		MYSN_DROME (1218-1932): 2.19e-38: 160: 23.06
+	Hs
		538642 MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		724737 MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		409452 MYL1_HUMAN (3-150): 1.84e-56: 176: 74.32		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		441666 MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		441674 MYL3_HUMAN (3-150): 2.39e-55: 173: 73.33		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		538643 MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		728458 MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00		MYH11_HUMAN (1684-2053): 3.04e-19: 97.5: 15.00
+	Hs
		725124 MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		538680 MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		891551 MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		484206 CALM3_HUMAN (5-77): 1.13e-11: 60.6: 28.77		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Hs
		484218 CALM3_HUMAN (5-77): 1.13e-11: 60.6: 28.77		MYO5B_HUMAN (1603-2051): 4.65e-14: 80.6: 9.19