Protein: SMAD3
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)

Gene: SMAD3
Organism: Mus musculus
Interactions: 40
UniProt ID: Q8BUN5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000165 - MAPK cascade
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1021510

SMAD4
Mothers against decapentaplegic homolog 4

8

18

Small-scale

0.958

High

518521

MYOD1
Myoblast determination protein 1

3

4

Small-scale

0.636

High

204547

SMAD7
Mothers against decapentaplegic homolog 7

1

18

Small-scale

0.618

High

871152

VDR
Vitamin D3 receptor

2

10

Small-scale

0.586

High

1063101

GATA4
Transcription factor GATA-4

1

8

Small-scale

0.573

High

629365

PO5F1
POU domain, class 5, transcription factor 1

1

1

Small-scale

0.554

High

1221350

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

5

Small-scale

0.536

High

205266

AXIN1
Axin-1

1

7

Small-scale

0.515

High

1221361

FSHB
Follitropin subunit beta

1

2

Small-scale

0.515

High

312718

FOXH1
Forkhead box protein H1

1

18

High-throughput

0.481

High

432096

JUN
Transcription factor Jun

1

9

Small-scale

0.481

High

1297412

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

20

Small-scale

0.481

High

205470

SOCS3
Suppressor of cytokine signaling 3

1

6

Small-scale

0.479

High

267139

PKNX1
Homeobox protein PKNOX1

1

11

Small-scale

0.479

High

464754

EGR1
Early growth response protein 1

1

5

Small-scale

0.479

High

465920

CO3A1

1

16

Small-scale

0.479

High

536209

CO1A1
Collagen alpha-1(I) chain

1

16

Small-scale

0.479

High

728528

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.479

High

790967

TAGL
Transgelin

1

2

Small-scale

0.479

High

835792

PBX1
Pre-B-cell leukemia transcription factor 1

1

9

Small-scale

0.479

High

862606

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.479

High

996075

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

1034864

SNAI1
Zinc finger protein SNAI1

1

6

Small-scale

0.479

High

1190305

SF3B2
Splicing factor 3B subunit 2

1

5

Small-scale

0.479

High

1222558

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.479

High

1223479

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

8

Small-scale

0.479

High

1223898

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

11

Small-scale

0.479

High

1274586

OTUB1
Ubiquitin thioesterase OTUB1

1

5

Small-scale

0.479

High

1281880

ERBIN
Erbin

1

10

Small-scale

0.479

High

1281911

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1297356

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

10

Small-scale

0.479

High

1297405

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1297406

PEX6
Peroxisomal ATPase PEX6

1

5

Small-scale

0.479

High

1297407

ZMYM2
Zinc finger MYM-type protein 2

1

5

Small-scale

0.479

High

1297410

4ET
Eukaryotic translation initiation factor 4E transporter

1

4

Small-scale

0.479

High

1297411

GSK3B
Glycogen synthase kinase-3 beta

1

8

Small-scale

0.479

High

1297409

IL23A
Interleukin-23 subunit alpha

1

0

Small-scale

0.458

High

604526

SPI1
Transcription factor PU.1

1

3

Small-scale

0.445

High

1297408

XPO7
Exportin-7

1

7

High-throughput

0.445

High

312010

CO5A1

1

16

Small-scale

0.437

High


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Last updated: 11Aug2025