HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 2725
+	Hs
		598031 ACTB_HUMAN (1-375): 0: 603: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		598053 ACTG_HUMAN (1-375): 0: 601: 98.93		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		598055 ACTC_HUMAN (2-375): 0: 592: 94.12		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		598045 ACTA_HUMAN (2-375): 0: 591: 94.12		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Mm
		892189 ACTB_MOUSE (1-375): 0: 603: 100.00		FLNB_MOUSE (146-2725): 0: 1194: 34.74
+	Hs
		261242 ACTC_HUMAN (2-375): 0: 592: 94.12		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		261239 ACTA_HUMAN (2-375): 0: 591: 94.12		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		725637 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00
+	Hs
		211548 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		211560 ACTC_HUMAN (2-375): 0: 592: 94.12		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		211561 ACTS_HUMAN (2-375): 0: 592: 93.58		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		363200 ACTBL_HUMAN (2-375): 0: 735: 91.71		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		891697 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		929824 ACTG_HUMAN (1-375): 0: 601: 98.93		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		932107 ACTC_HUMAN (2-375): 0: 592: 94.12		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Oc
		933099 ACTS_RABIT (2-375): 0: 592: 93.58		Q07931_RABIT (23-297): 1.19e-109: 353: 32.98
+	Hs
		362988 ACTB_HUMAN (1-375): 0: 603: 100.00		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		363051 ACTG_HUMAN (1-375): 0: 601: 98.93		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		506816 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB1_HUMAN (37-257): 1.25e-35: 152: 38.33
+	Dm
		284844 ACT1_DROME (2-375): 0: 598: 98.13		O77291_DROME (6-259): 3.31e-36: 154: 37.17