HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: CNN3 (Q15417)
Calponin-3 (Calponin, acidic isoform)
Gene: CNN3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005829 - cytosol GO:0005912 - adherens junction GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 329
+	Hs
		932175 ACTC_HUMAN (2-375): 0: 592: 94.12		CNN3_HUMAN (1-329): 6.62e-148: 421: 100.00
+	Hs
		891988 ACTB_HUMAN (1-375): 0: 603: 100.00		CNN2_HUMAN (2-311): 7.06e-117: 341: 65.48
+	Hs
		932344 ACTC_HUMAN (2-375): 0: 592: 94.12		CNN2_HUMAN (2-311): 7.06e-117: 341: 65.48
+	Hs
		851163 ACTS_HUMAN (2-375): 0: 592: 93.58		CNN1_HUMAN (2-280): 8.56e-115: 336: 71.69
+	Rn
		933100 ACTS_RAT (2-375): 0: 592: 93.58		CNN1_RAT (2-282): 1.06e-114: 335: 71.53
+	Hs
		891926 ACTB_HUMAN (1-375): 0: 603: 100.00		LMO7_HUMAN (36-293): 2.04e-65: 225: 19.37
+	Hs
		932285 ACTC_HUMAN (2-375): 0: 592: 94.12		LMO7_HUMAN (36-293): 2.04e-65: 225: 19.37
+	Hs
		741850 ACTB_HUMAN (1-375): 0: 603: 100.00		TAGL2_HUMAN (5-188): 1.11e-61: 196: 42.86
+	Hs
		741855 ACTG_HUMAN (1-375): 0: 601: 98.93		TAGL2_HUMAN (5-188): 1.11e-61: 196: 42.86
+	Hs
		741856 ACTC_HUMAN (2-375): 0: 592: 94.12		TAGL2_HUMAN (5-188): 1.11e-61: 196: 42.86
+	Hs
		892114 ACTB_HUMAN (1-375): 0: 603: 100.00		LIMC1_HUMAN (8-322): 3.08e-49: 178: 18.68
+	Dm
		862565 ACT3_DROME (2-375): 0: 594: 95.46		Q9I7J0_DROME (23-188): 1.37e-56: 182: 40.12
+	Hs
		809232 ACTB_HUMAN (1-375): 0: 603: 100.00		IQGA1_HUMAN (13-171): 1.22e-38: 147: 17.05
+	Hs
		809257 ACTG_HUMAN (1-375): 0: 601: 98.93		IQGA1_HUMAN (13-171): 1.22e-38: 147: 17.05
+	Sc
		887705 ACT_YEAST (1-375): 0: 591: 88.80		SCP1_YEAST (1-187): 5.3e-46: 156: 23.35
+	Hs
		891748 ACTB_HUMAN (1-375): 0: 603: 100.00		IQGA2_HUMAN (13-171): 3.19e-37: 143: 16.48
+	Sp
		144980 ACT_SCHPO (1-375): 0: 592: 90.40		IQG1_SCHPO (6-155): 6.14e-37: 142: 25.81
+	Sc
		887718 ACT_YEAST (1-375): 0: 591: 88.80		IQG1_YEAST (18-140): 6.58e-19: 89.8: 22.14