HitPredict

Interactor 1: FOSB (P53539)
Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)
Gene: FOSB

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21937452
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 338 Hs			1 2414
+	Hs
		548300 FOSL2_HUMAN (1-338): 9.55e-33: 125: 38.61		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		548240 FOSL1_HUMAN (54-338): 8.08e-31: 119: 39.04		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		547790 ATF2_HUMAN (8-299): 1.6e-28: 117: 16.34		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		345411 FOS_HUMAN (1-338): 8.95e-29: 116: 34.24		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		998764 NF2L2_HUMAN (7-218): 1.08e-25: 109: 22.97		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Mm
		70890 ATF2_MOUSE (8-302): 4.03e-26: 110: 16.03		EP300_MOUSE (1-2414): 0: 1090: 93.01
+	Hs
		345594 FOS_HUMAN (1-338): 8.95e-29: 116: 34.24		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		345579 FOS_HUMAN (1-338): 8.95e-29: 116: 34.24		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		401440 JUN_HUMAN (9-229): 4.9e-24: 102: 16.60		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		862628 FOSB_HUMAN (1-338): 5.83e-47: 163: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		1017305 NF2L2_HUMAN (7-218): 1.08e-25: 109: 22.97		BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86
+	Hs
		548258 FOSL1_HUMAN (54-338): 8.08e-31: 119: 39.04		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		345491 FOS_HUMAN (1-338): 8.95e-29: 116: 34.24		KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13
+	Hs
		345480 FOS_HUMAN (1-338): 8.95e-29: 116: 34.24		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92
+	Hs
		547833 ATF2_HUMAN (8-299): 1.6e-28: 117: 16.34		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		345507 FOS_HUMAN (1-338): 8.95e-29: 116: 34.24		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Mm
		101443 NF2L2_MOUSE (7-218): 3.5e-28: 116: 21.97		F8VPR5_MOUSE (1752-2401): 7.8e-10: 67.1: 12.31
+	Hs
		401362 JUN_HUMAN (9-229): 4.9e-24: 102: 16.60		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23
+	Hs
		1081236 NF2L2_HUMAN (7-218): 1.08e-25: 109: 22.97		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		579220 ATF3_HUMAN (149-237): 5.19e-27: 106: 43.82		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25