HitPredict

Interactor 1: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.922

The method score is based on:

Property Details
Experiments 29395067, 28514442, 33961781, 35235311, 34349018
Identification Methods proximity labelling technology, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~DEAD, DEAD~Helicase_C, Helicase_C~Helicase_C
Common GO terms GO:0002183 - cytoplasmic translational initiation
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0003743 - translation initiation factor activity
GO:0004386 - helicase activity
and 5 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 406
Hs

1 407
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Last updated: 15 Jul 2024