Protein: SYF1
Pre-mRNA-splicing factor SYF1 (PRP19-associated complex protein 90) (Synthetic lethal with CDC40 protein 1)

Gene: SYF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 79
UniProt ID: Q04048

Gene Ontology (top 5):
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1043502

CEF1
Pre-mRNA-splicing factor CEF1

13

13

Small-scale

0.761

High

638082

ISY1
Pre-mRNA-splicing factor ISY1

10

6

Small-scale

0.761

High

739198

PRP19
Pre-mRNA-processing factor 19

12

19

Small-scale

0.760

High

797689

NTC20
Pre-mRNA-splicing factor NTC20

8

1

Small-scale

0.755

High

919219

SYF2
Pre-mRNA-splicing factor SYF2

8

1

Small-scale

0.752

High

1044955

CLF1
Pre-mRNA-splicing factor CLF1

8

12

Small-scale

0.752

High

702281

YJU2
Splicing factor YJU2

8

5

Small-scale

0.749

High

700143

PRP45
Pre-mRNA-processing protein 45

7

7

Small-scale

0.746

High

1044952

CWC2
Pre-mRNA-splicing factor CWC2

5

8

Small-scale

0.718

High

751785

PRP8
Pre-mRNA-splicing factor 8

5

11

Small-scale

0.714

High

1044945

SN309
Pre-mRNA-splicing factor SNT309

4

1

Small-scale

0.697

High

744160

BRR2
Pre-mRNA-splicing helicase BRR2

4

20

Small-scale

0.686

High

1044951

RU2A
U2 small nuclear ribonucleoprotein A'

4

8

Small-scale

0.686

High

817160

RSMB
Small nuclear ribonucleoprotein-associated protein B

3

12

High-throughput

0.656

High

1044947

SP382
Pre-mRNA-splicing factor SPP382

2

3

Small-scale

0.628

High

781586

NTR2
Pre-mRNA-splicing factor NTR2

2

1

Small-scale

0.611

High

919730

CWC22
Pre-mRNA-splicing factor CWC22

2

2

High-throughput

0.611

High

1044956

PRP46
Pre-mRNA-splicing factor PRP46

2

19

High-throughput

0.611

High

847829

SMD3
Small nuclear ribonucleoprotein Sm D3

2

20

High-throughput

0.601

High

664620

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

2

20

Small-scale

0.595

High

402108

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

5

Small-scale

0.584

High

628229

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

2

20

High-throughput

0.584

High

757533

NCBP1
Nuclear cap-binding protein complex subunit 1

2

3

High-throughput

0.584

High

780221

SN114
Pre-mRNA-splicing factor SNU114

2

15

Small-scale

0.584

High

1036175

SMD1
Small nuclear ribonucleoprotein Sm D1

2

3

Small-scale

0.584

High

1044950

NCBP2
Nuclear cap-binding protein subunit 2

2

20

High-throughput

0.584

High

923938

CWC25
Pre-mRNA-splicing factor CWC25

2

1

High-throughput

0.571

High

819703

SSB2
Ribosome-associated molecular chaperone SSB2

2

12

High-throughput

0.552

High

1044075

VHS1
Serine/threonine-protein kinase VHS1

1

1

High-throughput

0.536

High

814264

RV167
Reduced viability upon starvation protein 167

1

3

High-throughput

0.515

High

863129

RRP41
Exosome complex component SKI6

1

10

High-throughput

0.508

High

1044942

SYF1
Pre-mRNA-splicing factor SYF1

1

10

Small-scale

0.508

High

835992

HKR1
Signaling mucin HKR1

1

6

High-throughput

0.494

High

918871

DRN1
CWF19-like protein DRN1

1

2

Small-scale

0.481

High

590222

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

20

High-throughput

0.479

High

625129

PRP9
Pre-mRNA-splicing factor PRP9

1

3

High-throughput

0.479

High

672074

BUD31
Pre-mRNA-splicing factor BUD31

1

5

High-throughput

0.479

High

708082

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

739275

PRP21
Pre-mRNA-splicing factor PRP21

1

6

High-throughput

0.479

High

780857

MUD2
Splicing factor MUD2

1

1

Small-scale

0.479

High

796462

SLT11
Pre-mRNA-splicing factor SLT11

1

5

High-throughput

0.479

High

820837

RUXG
Small nuclear ribonucleoprotein G

1

20

High-throughput

0.479

High

826525

IST3
U2 snRNP component IST3

1

12

High-throughput

0.479

High

826549

MSL1
U2 small nuclear ribonucleoprotein B''

1

20

High-throughput

0.479

High

829957

PRP17
Pre-mRNA-processing factor 17

1

20

High-throughput

0.479

High

863097

CWC26
Pre-mRNA-splicing factor CWC26

1

3

High-throughput

0.479

High

892785

SF3B1
U2 snRNP component HSH155

1

9

High-throughput

0.479

High

933139

RUXF
Small nuclear ribonucleoprotein F

1

12

High-throughput

0.479

High

1037091

SPP2
Pre-mRNA-splicing factor SPP2

1

1

High-throughput

0.479

High

1037752

CUS1
Cold sensitive U2 snRNA suppressor 1

1

3

High-throughput

0.479

High

1038498

CWC27
Peptidyl-prolyl isomerase CWC27

1

3

High-throughput

0.479

High

1038538

SLU7
Pre-mRNA-splicing factor SLU7

1

2

High-throughput

0.479

High

1042531

CWC21
Pre-mRNA-splicing factor CWC21

1

2

High-throughput

0.479

High

1044020

CWC15
Pre-mRNA-splicing factor CWC15

1

1

High-throughput

0.479

High

1044943

PDS5
Sister chromatid cohesion protein PDS5

1

3

High-throughput

0.479

High

1044944

RSE1
Pre-mRNA-splicing factor RSE1

1

4

High-throughput

0.479

High

1044946

SMD2
Small nuclear ribonucleoprotein Sm D2

1

6

High-throughput

0.479

High

1044948

RDS3
Pre-mRNA-splicing factor RDS3

1

2

High-throughput

0.479

High

1044949

PRP11
Pre-mRNA-splicing factor PRP11

1

4

High-throughput

0.479

High

1044953

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

1044957

HSH49
Protein HSH49

1

7

High-throughput

0.479

High

1044958

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

5

Small-scale

0.479

High

727684

TPS2
Trehalose-phosphatase

1

2

High-throughput

0.470

High

747163

RT04
Small ribosomal subunit protein uS2m

1

3

High-throughput

0.464

High

752050

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.458

High

525041

HSP71
Heat shock protein SSA1

1

11

High-throughput

0.445

High

527592

HSP72
Heat shock protein SSA2

1

11

High-throughput

0.445

High

546148

SSB1
Ribosome-associated molecular chaperone SSB1

1

12

High-throughput

0.445

High

671084

SIS1
Protein SIS1

1

5

High-throughput

0.445

High

1044954

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.426

High

863720

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

746075

SEC6
Exocyst complex component SEC6

1

0

High-throughput

0.269

Low

793396

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

0

High-throughput

0.269

Low

758357

MTC2
Maintenance of telomere capping protein 2

1

0

High-throughput

0.265

Low

806260

SSP1
Sporulation-specific protein 1

1

0

High-throughput

0.265

Low

649669

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.261

Low

605926

HPR1
THO complex subunit HPR1

1

0

Small-scale

0.249

Low

672455

STE50
Protein STE50

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025