HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	32296183, 19549727, 32814053, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 406
+	Hs
		849312 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		988038 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		896360 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		1304199 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		849421 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		896370 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM5_HUMAN (39-392): 3.48e-68: 225: 14.85
+	Hs
		1318719 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRIM5_HUMAN (39-392): 3.48e-68: 225: 14.85
+	Hs
		849439 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		TRIM5_HUMAN (39-392): 3.48e-68: 225: 14.85
+	Hs
		896344 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN138_HUMAN (31-190): 6.27e-46: 160: 18.68
+	Hs
		896362 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		1261313 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN138_HUMAN (31-190): 6.27e-46: 160: 18.68
+	Hs
		749302 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		849366 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		TRI22_HUMAN (41-392): 2.66e-43: 159: 10.50
+	Hs
		584907 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		896381 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI39_HUMAN (39-392): 2e-35: 138: 13.84
+	Hs
		896366 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI34_HUMAN (39-392): 1.13e-34: 136: 10.43
+	Hs
		849377 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		COP1_HUMAN (40-326): 3.5e-39: 151: 18.31
+	Hs
		849423 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		749252 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		1336390 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI39_HUMAN (39-392): 2e-35: 138: 13.84