HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.980

Property	Details
Experiments	16714285, 27173435, 32451438, 25416956, 28514442, 32296183, 33961781, 19549727, 32814053, unassigned1304
Identification Methods	affinity chromatography technology, pull down, two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array, tandem affinity purification, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 245
+	Hs
		1261313 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN138_HUMAN (1-245): 6.92e-57: 183: 100.00
+	Hs
		896346 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN166_HUMAN (5-244): 4.23e-40: 140: 29.58
+	Hs
		896402 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN114_HUMAN (16-241): 4.34e-36: 129: 30.53
+	Hs
		896352 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN125_HUMAN (2-243): 3.21e-33: 122: 26.86
+	Hs
		1283434 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN166_HUMAN (5-244): 4.23e-40: 140: 29.58
+	Hs
		896348 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI43_HUMAN (6-245): 1.85e-29: 116: 15.29
+	Hs
		896381 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI39_HUMAN (9-186): 1.44e-28: 114: 17.22
+	Hs
		896370 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM5_HUMAN (5-160): 2.04e-28: 113: 14.91
+	Hs
		896360 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RING2_HUMAN (2-188): 8.11e-29: 112: 18.72
+	Hs
		896376 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RNF41_HUMAN (1-158): 7.35e-29: 112: 20.96
+	Hs
		1377466 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25
+	Hs
		896369 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI31_HUMAN (6-156): 1.18e-25: 105: 17.65
+	Hs
		1290204 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN125_HUMAN (2-243): 3.21e-33: 122: 26.86
+	Hs
		1285831 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI43_HUMAN (6-245): 1.85e-29: 116: 15.29
+	Hs
		1336390 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI39_HUMAN (9-186): 1.44e-28: 114: 17.22
+	Hs
		1318719 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRIM5_HUMAN (5-160): 2.04e-28: 113: 14.91
+	Hs
		896302 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RING1_HUMAN (2-74): 3.94e-21: 92.7: 27.40
+	Hs
		1304199 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RING2_HUMAN (2-188): 8.11e-29: 112: 18.72
+	Hs
		1318532 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI31_HUMAN (6-156): 1.18e-25: 105: 17.65
+	Hs
		988038 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RING1_HUMAN (2-74): 3.94e-21: 92.7: 27.40