Protein: GCDH
Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)

Gene: GCDH
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q92947

Gene Ontology (top 5):
GO:0000062 - fatty-acyl-CoA binding
GO:0004361 - glutaryl-CoA dehydrogenase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006568 - L-tryptophan metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1162459

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

4

Small-scale

0.640

High

1370908

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

14

High-throughput

0.618

High

1370889

SYMM
Methionine--tRNA ligase, mitochondrial

2

3

High-throughput

0.611

High

1370897

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

2

1

High-throughput

0.611

High

713123

NOS3
Nitric oxide synthase 3

1

2

High-throughput

0.590

High

242492

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

890029

PSN1
Presenilin-1

1

1

High-throughput

0.576

High

1370893

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

3

High-throughput

0.541

High

61567

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.536

High

1310284

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

1370910

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.513

High

369719

A2MG
Alpha-2-macroglobulin

1

2

High-throughput

0.494

High

564159

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.489

High

282027

MPPB
Mitochondrial-processing peptidase subunit beta

1

8

High-throughput

0.479

High

287342

RF1M
Peptide chain release factor 1, mitochondrial

1

6

High-throughput

0.479

High

350938

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

4

High-throughput

0.479

High

471162

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

6

High-throughput

0.479

High

519183

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

3

High-throughput

0.479

High

786197

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

828876

MDHM
Malate dehydrogenase, mitochondrial

1

7

High-throughput

0.479

High

841853

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

851972

EFTS
Elongation factor Ts, mitochondrial

1

4

High-throughput

0.479

High

856324

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

1048618

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1058180

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1083688

MPPA
Mitochondrial-processing peptidase subunit alpha

1

8

High-throughput

0.479

High

1117793

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

9

High-throughput

0.479

High

1207087

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

1370884

FAKD4
FAST kinase domain-containing protein 4

1

5

High-throughput

0.479

High

1370885

MFRN2
Mitoferrin-2

1

5

High-throughput

0.479

High

1370888

RRFM
Ribosome-recycling factor, mitochondrial

1

2

High-throughput

0.479

High

1370891

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.479

High

1370892

IMP2L
Mitochondrial inner membrane protease subunit 2

1

6

High-throughput

0.479

High

1370895

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1370896

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1370898

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

1370899

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

1370903

BRD8
Bromodomain-containing protein 8

1

6

High-throughput

0.479

High

1370905

MTG2
Mitochondrial ribosome-associated GTPase 2

1

8

High-throughput

0.479

High

1370907

MET17
Ribosome assembly protein METTL17, mitochondrial

1

4

High-throughput

0.479

High

1370915

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

6

High-throughput

0.479

High

1092

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

1209471

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1370920

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.445

High

890764

PSN2
Presenilin-2

1

1

High-throughput

0.439

High

1370919

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

2

High-throughput

0.439

High

106401

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

174579

TRI66
Tripartite motif-containing protein 66

1

2

High-throughput

0.437

High

342281

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.437

High

458457

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.437

High

472948

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

639793

TAF1
Transcription initiation factor TFIID subunit 1

1

6

High-throughput

0.437

High

659276

SP100
Nuclear autoantigen Sp-100

1

2

High-throughput

0.437

High

696122

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

768810

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

831176

CCNF
Cyclin-F

1

3

High-throughput

0.437

High

879332

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

920158

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.437

High

962348

RHOA
Transforming protein RhoA

1

3

High-throughput

0.437

High

987829

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.437

High

1095738

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.437

High

1113907

CUL3
Cullin-3

1

2

High-throughput

0.437

High

1151809

RHOH
Rho-related GTP-binding protein RhoH

1

4

High-throughput

0.437

High

1178287

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1249075

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1254918

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1334719

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.437

High

1359679

PHIP
PH-interacting protein

1

1

High-throughput

0.437

High

1370886

FAF2
FAS-associated factor 2

1

3

High-throughput

0.437

High

1370887

OPTN
Optineurin

1

2

High-throughput

0.437

High

1370890

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

1370901

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

1370904

RHOJ
Rho-related GTP-binding protein RhoJ

1

4

High-throughput

0.437

High

1370906

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1370909

BRD7
Bromodomain-containing protein 7

1

6

High-throughput

0.437

High

1370916

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

1370918

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.437

High

1156353

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

Small-scale

0.426

High

1370911

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

652225

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

4

High-throughput

0.407

High

1227197

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

1335662

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

1348613

S7A14
Solute carrier family 7 member 14

1

3

High-throughput

0.407

High

1370913

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

1370921

X6RFA8
Solute carrier family 25 member 28

1

4

High-throughput

0.407

High

387448

APOE
Apolipoprotein E

1

0

High-throughput

0.282

High

1158461

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.282

High

1347235

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.282

High

1370902

RNF32
RING finger protein 32

1

0

High-throughput

0.282

High

372754

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.279

Low

1034793

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1120483

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1370894

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.279

Low

1370900

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

1370914

KLHL8
Kelch-like protein 8

1

0

High-throughput

0.279

Low

1121293

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

1128798

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

1135763

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low

1370912

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

1370917

TES
Testin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025