HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.872

Property	Details
Experiments	11513855, 19549727, 32814053
Identification Methods	pull down, two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 336
+	Hs
		1304199 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		896302 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		988038 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		896381 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67
+	Hs
		896348 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI43_HUMAN (45-303): 1.25e-47: 168: 13.11
+	Hs
		1336390 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67
+	Hs
		1285831 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI43_HUMAN (45-303): 1.25e-47: 168: 13.11
+	Hs
		896362 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		536773 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI27_HUMAN (36-282): 4.98e-37: 141: 16.08
+	Hs
		896370 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM5_HUMAN (38-285): 1.54e-36: 139: 14.23
+	Hs
		1313765 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI62_HUMAN (45-334): 1.43e-43: 157: 13.85
+	Hs
		584907 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RO52_HUMAN (36-286): 4.69e-43: 156: 13.55
+	Hs
		749302 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		536760 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		TRI27_HUMAN (36-282): 4.98e-37: 141: 16.08
+	Hs
		537142 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI27_HUMAN (36-282): 4.98e-37: 141: 16.08
+	Hs
		1318719 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRIM5_HUMAN (38-285): 1.54e-36: 139: 14.23
+	Hs
		896344 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN138_HUMAN (34-201): 1.75e-27: 109: 17.06
+	Hs
		551428 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RAG1_HUMAN (42-197): 1.72e-29: 121: 20.51
+	Hs
		1290127 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		CHFR_HUMAN (18-224): 6.7e-29: 119: 17.84
+	Hs
		1261313 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN138_HUMAN (34-201): 1.75e-27: 109: 17.06