Protein: SPDEF
SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor)

Gene: SPDEF
Organism: Homo sapiens
Interactions: 36
UniProt ID: O95238

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002068 - glandular epithelial cell development
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

331504

MECOM
Histone-lysine N-methyltransferase MECOM

3

2

High-throughput

0.667

High

331523

PRD16
Histone-lysine N-methyltransferase PRDM16

3

2

High-throughput

0.667

High

331520

NKX31
Homeobox protein Nkx-3.1

2

20

Small-scale

0.619

High

331505

U119A
Protein unc-119 homolog A

3

1

High-throughput

0.609

High

331525

MYO5C
Unconventional myosin-Vc

3

2

High-throughput

0.609

High

331511

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

2

0

High-throughput

0.585

High

331501

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.580

High

331513

CEP57
Centrosomal protein of 57 kDa

2

0

High-throughput

0.580

High

331528

CD11A
Cyclin-dependent kinase 11A

1

3

Small-scale

0.578

High

331526

ANM8
Protein arginine N-methyltransferase 8

2

1

High-throughput

0.574

High

331512

SNX20
Sorting nexin-20

2

1

High-throughput

0.553

High

331502

PCGF2
Polycomb group RING finger protein 2

1

12

High-throughput

0.541

High

331498

ANDR
Androgen receptor

1

15

Small-scale

0.501

High

331503

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.501

High

65994

U119B
Protein unc-119 homolog B

1

1

High-throughput

0.489

High

331527

KLHL9
Kelch-like protein 9

1

5

High-throughput

0.489

High

331508

STK11
Serine/threonine-protein kinase STK11

1

1

Small-scale

0.481

High

222606

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

331500

CD11B
Cyclin-dependent kinase 11B

1

3

Small-scale

0.479

High

331506

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

331516

ESR2
Estrogen receptor beta

1

15

High-throughput

0.479

High

331522

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

128691

MEN1
Menin

1

0

High-throughput

0.458

High

331514

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

331507

PLEC
Plectin

1

2

High-throughput

0.437

High

331497

B3A2
Anion exchange protein 2

3

0

High-throughput

0.347

High

331509

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

3

0

High-throughput

0.347

High

331517

MACIR
Macrophage immunometabolism regulator

3

0

High-throughput

0.347

High

331499

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

2

0

High-throughput

0.316

High

331510

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

331518

F161B
Protein FAM161B

2

0

High-throughput

0.316

High

331521

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

160856

STX16
Syntaxin-16

1

0

High-throughput

0.269

Low

331519

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.269

Low

331515

BRK1
Protein BRICK1

1

0

High-throughput

0.268

Low

331524

ANLN
Anillin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025