HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 28244869, 31638574, 34799425, 19549727, 17709375, 24610907, 25548215, 27791197, 27173435, 27918549, 27695001, 29537486, 29432170, 29950522, 31074699, 30979779, 31578830, 11057907, 34490261, 21113135 and 7 others

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Identification Methods two hybrid, x-ray crystallography, affinity chromatography technology, enzymatic study, pull down, molecular sieving, surface plasmon resonance, tandem affinity purification, two hybrid array
Interaction Type direct interaction, association, physical association, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~zf-C3HC4_2
Common GO terms GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0032991 - protein-containing complex
and 5 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024